ArticleCell2012
Maternal-fetal immune tolerance, block by block.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Human embryo implantation.Development (Cambridge, England) · 2023Review
- Gene loss and co-option of toll-like receptors facilitate paternal immunological adaptation in the brood pouch of pregnant male seahorses.Frontiers in immunology · 2023Article
- Exploring the role of T helper subgroups and their cytokines in the development of pregnancy-induced hypertension.Frontiers in immunology · 2023Article
- Role of CNSs Conserved Distal Cis-Regulatory Elements in CD4 + T Cell Development and Differentiation.Frontiers in immunology · 2022Review
- Oestrogen receptor α in T cells controls the T cell immune profile and glucose metabolism in mouse models of gestational diabetes mellitus.Diabetologia · 2021Article
- Interactions Between Specific Immune Status of Pregnant Women and SARS-CoV-2 Infection.Frontiers in cellular and infection microbiology · 2021Review
- Comparative analysis of immune related genes between domestic pig and germ-free minipig.Laboratory animal research · 2020Article
- Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy.International journal of biological sciences · 2020Review
- The Pregnancy Pickle: Evolved Immune Compensation Due to Pregnancy Underlies Sex Differences in Human Diseases.Trends in genetics : TIG · 2019Review
- Sex Differences in Melanoma.Current epidemiology reports · 2019Article
- Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia.Cellular & molecular immunology · 2019Article
- Exploring the links between cancer and placenta development.Open biology · 2018Review
- Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics.International journal of tryptophan research : IJTR · 2017Review
- Placental immune editing switch (PIES): learning about immunomodulatory pathways from a unique case report.Oncotarget · 2016Article
- VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast-maternal leukocyte interaction.Journal of leukocyte biology · 2015Article
- The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals.Frontiers in immunology · 2015Article
- Amniotic fluid RNA gene expression profiling provides insights into the phenotype of Turner syndrome.Human genetics · 2014Article
- Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.