Evidence map›Paper›PMID 22770210›Full record

ArticleCell2012

Maternal-fetal immune tolerance, block by block.

Michael Gobert, Juan J Lafaille

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Human embryo implantation.Development (Cambridge, England) · 2023
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy.International journal of biological sciences · 2020
    Review
  9. Review
  10. Sex Differences in Melanoma.Current epidemiology reports · 2019
    Article
  11. Article
  12. Review
  13. Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics.International journal of tryptophan research : IJTR · 2017
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael Gobert
Juan J Lafaille
New York University · US

Funding

Characterization of lymphocytes that suppress EAER56AI041647 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LAFAILLE, JUAN · 2009 to 2010
$821k
Thymic selection of Foxp3+ regulatory T cellsR56AI088553 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LAFAILLE, JUAN · 2010 to 2010
$423k
NIAID NIH HHS R56 AI041647NIAID NIH HHS R56 AI088553
6 · The paper itself

Abstract

How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance.

Identifiers

PMID22770210
PMCPMC4061910
OpenAlexW2035358488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.