ArticleNanotoxicology2013
Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts.
Article in Nanotoxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Genotoxicity Evaluation of Titanium Dioxide Nanoparticles In Vitro: a Systematic Review of the Literature and Meta-analysis.Biological trace element research · 2021Pooled it
- Immune-epigenetic convergence in biomaterial-guided tissue regeneration.Materials today. Bio · 2026Article
- Histone modification changes upon exposure of human lung adenocarcinoma cells to nanoparticles.Scientific reports · 2025Article
- Titanium dioxide nanoparticles: a promising candidate for wound healing applications.Burns & trauma · 2025Review
- DNA Damage and Apoptosis as In-Vitro Effect Biomarkers of Titanium Dioxide Nanoparticles (TiOInternational journal of environmental research and public health · 2023Article
- High-Throughput Screening Platform for Nanoparticle-Mediated Alterations of DNA Repair Capacity.ACS nano · 2021Article
- Epigenetic Effects of Nanomaterials and Nanoparticles.Journal of nanobiotechnology · 2021Review
- TiOInternational journal of nanomedicine · 2020Article
- Article
- Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways.International journal of molecular sciences · 2017Review
- Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the γ-H2AX and NF-κB signaling pathways.Oncotarget · 2017Article
- Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer.Molecular cancer therapeutics · 2015Article
- Titanium Dioxide Nanoparticles are not Cytotoxic or Clastogenic in Human Skin Cells.Journal of environmental & analytical toxicology · 2014Article
- Titanium dioxide nanoparticles: a review of current toxicological data.Particle and fibre toxicology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The use of nanoparticles in consumer products increases their prevalence in the environment and the potential risk to human health. Although recent studies have shown in vivo and in vitro toxicity of titanium dioxide nanoparticles (nano-TiO2), a more detailed view of the underlying mechanisms of this response needs to be established. Here, the effects of nano-TiO2 on the DNA damage response and DNA replication dynamics were investigated in human dermal fibroblasts. Specifically, the relationship between nano-TiO2 and the DNA damage response pathways regulated by ATM/Chk2 and ATR/Chk1 was examined. The results show increased phosphorylation of H2AX, ATM, and Chk2 after exposure. In addition, nano-TiO2 inhibited the overall rate of DNA synthesis and frequency of replicon initiation events in DNA-combed fibres. Taken together, these results demonstrate that exposure to nano-TiO2 activates the ATM/Chk2 DNA damage response pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.