ArticleACS chemical biology2012
Detection of highly curved membrane surfaces using a cyclic peptide derived from synaptotagmin-I.
Article in ACS chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons.Nature communications · 2025Article
- [Research progress of peptide recognition-guided strategies for exosome isolation and enrichment].Se pu = Chinese journal of chromatography · 2025Review
- Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.Journal of extracellular vesicles · 2024Article
- Summary of Prof. Yin's CSEMV-EVCNA award lecture 2021.Extracellular vesicles and circulating nucleic acids · 2022Article
- Amphipathic helical peptide-based fluorogenic probes for a marker-free analysis of exosomes based on membrane-curvature sensing.RSC advances · 2020Article
- Functional peptides for cartilage repair and regeneration.American journal of translational research · 2018Article
- Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine.Scientific reports · 2017Article
- Metal-Assisted Folding of Prolinomycin Allows Facile Design of Functional Peptides.Chembiochem : a European journal of chemical biology · 2017Article
- Drugging Membrane Protein Interactions.Annual review of biomedical engineering · 2016Review
- Determinants of Curvature-Sensing Behavior for MARCKS-Fragment Peptides.Biophysical journal · 2016Article
- Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization.Journal of medicinal chemistry · 2016Article
- Curvature sensing MARCKS-ED peptides bind to membranes in a stereo-independent manner.Journal of peptide science : an official publication of the European Peptide Society · 2015Article
- Targeting protein-protein interfaces using macrocyclic peptides.Biopolymers · 2015Review
- Synaptotagmin's role in neurotransmitter release likely involves Ca(2+)-induced conformational transition.Biophysical journal · 2014Article
- Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes.Chembiochem : a European journal of chemical biology · 2014Review
- Solution phase conformation and proteolytic stability of amide-linked neuraminic acid analogues.Biopolymers · 2013Article
- The click reaction as an efficient tool for the construction of macrocyclic structures.Molecules (Basel, Switzerland) · 2013Review
- Multivalency amplifies the selection and affinity of bradykinin-derived peptides for lipid nanovesicles.Molecular bioSystems · 2013Article
- Illuminating the lipidome to advance biomedical research: peptide-based probes of membrane lipids.Future medicinal chemistry · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The generation of highly curved membranes is essential to cell growth, division, and movement. Recent research in the field is focused to answer questions related to the consequences of changes in the topology of the membrane once it is created, broadly termed as membrane curvature sensing. Most probes that are used to study curvature sensing are intact membrane active proteins such as DP1/Yop1p, ArfGAP1, BAR domains, and Synaptotagmin-I (Syt1). Taking a cue from nature, we created the cyclic peptide C2BL3C based on the membrane penetration C2B loop 3 of Syt1 via "Click" chemistry. Using a combination of spectroscopic techniques, we investigated the peptide-lipid interactions of this peptide with synthetic phospholipid vesicles and exosomes from rat blood plasma. We found that the macrocycle peptide probe was selective for lipid vesicles with highly curved surfaces (d < 100 nm). These results suggested that C2BL3C functions as a selective detector of highly curved phospholipid bilayers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.