ArticleOral surgery, oral medicine, oral pathology and oral radiology2012
Oral fluids that detect cardiovascular disease biomarkers.
Article in Oral surgery, oral medicine, oral pathology and oral radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Saliva as an alternative to blood in the determination of uremic state in adult patients with chronic kidney disease: a systematic review and meta-analysis.Clinical oral investigations · 2020Pooled it
- Saliva as a diagnostic tool to measure polycyclic aromatic hydrocarbon exposure in dental patients exposed to intimate partner violence (IPV).Biomedical journal · 2023Article
- High-Sensitive Cardiospecific Troponins: The Role of Gender-Specific Concentration in the Diagnosis of Acute Coronary Syndrome (Descriptive Review).Reviews in cardiovascular medicine · 2023Review
- Modern View on the Role of Sex-Specific Levels of High-Sensitive Cardiospecific Troponins T and I in the Diagnosis of Myocardial Infarction.Cardiology research · 2023Review
- Gender Specificities of Cardiac Troponin Serum Levels: From Formation Mechanisms to the Diagnostic Role in Case of Acute Coronary Syndrome.Life (Basel, Switzerland) · 2023Review
- Diagnostic performance of oral swab specimen for SARS-CoV-2 detection with rapid point-of-care lateral flow antigen test.Scientific reports · 2022Article
- Salivary Biomarkers for Diagnosis and Therapy Monitoring in Patients with Heart Failure. A Systematic Review.Diagnostics (Basel, Switzerland) · 2021Review
- Saliva profiles in children with congenital heart disease.European oral research · 2020Article
- Salivary Glycopatterns as Potential Biomarkers for Screening of Early-Stage Breast Cancer.EBioMedicine · 2018Article
- Detection of Plasmodium falciparum DNA in saliva samples stored at room temperature: potential for a non-invasive saliva-based diagnostic test for malaria.Malaria journal · 2017Article
- Review
- A pilot study of salivary N-glycome in HBV-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma.Glycoconjugate journal · 2017Article
- Identification and Validation of a Salivary Protein Panel to Detect Heart Failure Early.Theranostics · 2017Article
- The dental calculus metabolome in modern and historic samples.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- Rapid assessment of salivary MMP-8 and periodontal disease using lateral flow immunoassay.Oral diseases · 2016Article
- Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Salivary and serum procalcitonin and C-reactive protein as biomarkers of periodontitis in United States veterans with osteoarthritis or rheumatoid arthritis.Biotechnic & histochemistry : official publication of the Biological Stain Commission · 2016Article
- Utility of salivary biomarkers for demonstrating acute myocardial infarction.Journal of dental research · 2014Article
- Influence of Intimate Partner Violence (IPV) Exposure on Cardiovascular and Salivary Biosensors: Is There a Relationship?Journal of the National Medical AssociationArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to determine the utility of oral fluids for assessment of coronary and cardiovascular (CV) health. STUDY
designTwenty-nine patients with preexisting CV disease underwent an invasive cardiac procedure (alcohol septal ablation or percutaneous coronary intervention) and provided unstimulated whole saliva (UWS), sublingual swabs (LS), gingival swabs (GS) and serum at 0, 8, 16, 24, and 48 hours. Concentrations of 13 relevant biomarkers were determined and correlated with levels in serum and the oral fluids.
resultsConcentrations of the majority of biomarkers were higher in UWS than in LS and GS. Coronary and CV disease biomarkers in UWS correlated better with serum than with LS and GS based on group status and measures of time effect. Seven biomarkers demonstrated time effect changes consistent with serum biomarkers, including C-reactive protein and troponin I.
conclusionsChanges in serum biomarker profiles are reflected in oral fluids suggesting that oral fluid biomarkers could aid in the assessment of cardiac ischemia/necrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.