ArticlePsychiatry research2012
Greater executive and visual memory dysfunction in comorbid bipolar disorder and substance use disorder.
Article in Psychiatry research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature.Neuroscience and biobehavioral reviews · 2016Pooled it
- Domain-Specific Memory Impairments in Bipolar Mania: Insights from a Tertiary Care Hospital.Indian journal of psychological medicine · 2025Article
- Assessment of cognitive function in bipolar disorder with passive smartphone keystroke metadata: a BiAffect digital phenotyping study.Frontiers in psychiatry · 2025Article
- Patients with Schizophrenia Showed Worse Cognitive Performance than Bipolar and Major Depressive Disorder in a Sample with Comorbid Substance Use Disorders.Journal of clinical medicine · 2022Article
- Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder.Brain sciences · 2021Article
- Cognitive impairment in individuals with bipolar disorder with and without comorbid alcohol and/or cocaine use disorders.Journal of affective disorders · 2020Article
- Cohort Profile: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder.International journal of epidemiology · 2018Article
- Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents.Journal of neuroscience research · 2017Article
- Effect of alcohol and illicit substance use on verbal memory among individuals with bipolar disorder.Psychiatry research · 2016Article
- Unraveling Executive Functioning in Dual Diagnosis.Frontiers in psychology · 2016Review
- Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates.Frontiers in physiology · 2015Review
- Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events.International journal of bipolar disorders · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Measures of cognitive dysfunction in Bipolar Disorder (BD) have identified state and trait dependent metrics. An influence of substance abuse (SUD) on BD has been suggested. This study investigates potential differential, additive, or interactive cognitive dysfunction in bipolar patients with or without a history of SUD. Two hundred fifty-six individuals with BD, 98 without SUD and 158 with SUD, and 97 Healthy Controls (HC) completed diagnostic interviews, neuropsychological testing, and symptom severity scales. The BD groups exhibited poorer performance than the HC group on most cognitive factors. The BD with SUD exhibited significantly poorer performance than BD without SUD in visual memory and conceptual reasoning/set-shifting. In addition, a significant interaction effect between substance use and depressive symptoms was found for auditory memory and emotion processing. BD patients with a history of SUD demonstrated worse visual memory and conceptual reasoning skills above and beyond the dysfunction observed in these domains among individuals with BD without SUD, suggesting greater impact on integrative, gestalt-driven processing domains. Future research might address longitudinal outcome as a function of BD, SUD, and combined BD/SUD to evaluate neural systems involved in risk for, and effects of, these illnesses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.