ArticleBiophysical journal2012
Can the sodium-calcium exchanger initiate or suppress calcium sparks in cardiac myocytes?
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Gerrymandering in the heart: How tissue heterogeneities promote premature ventricular contractions.Biophysical journal · 2026Article
- Multi-Scale Computational Modeling of Spatial Calcium Handling From Nanodomain to Whole-Heart: Overview and Perspectives.Frontiers in physiology · 2022Review
- Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves.The Journal of physiology · 2021Article
- Size Matters: Ryanodine Receptor Cluster Size Heterogeneity Potentiates Calcium Waves.Biophysical journal · 2019Article
- A model for cooperative gating of L-type Ca2+ channels and its effects on cardiac alternans dynamics.PLoS computational biology · 2018Article
- Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B-deficient hearts.Cardiovascular research · 2016Article
- Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks.Biophysical journal · 2016Article
- Depolarization of cardiac membrane potential synchronizes calcium sparks and waves in tissue.Biophysical journal · 2014Article
- Junctional cleft [Ca²⁺]i measurements using novel cleft-targeted Ca²⁺ sensors.Circulation research · 2014Article
- The role of dyadic organization in regulation of sarcoplasmic reticulum Ca(2+) handling during rest in rabbit ventricular myocytes.Biophysical journal · 2014Article
- Mitochondrial calcium uptake.Proceedings of the National Academy of Sciences of the United States of America · 2013Review
- Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses.Cardiovascular research · 2013Review
- Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes.The Journal of physiology · 2013Article
- Cardiac electrophysiological dynamics from the cellular level to the organ level.Biomedical engineering and computational biology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Positive feedback of Calcium (Ca)-induced Ca release is the mechanism of Ca spark formation in cardiac myocytes. To initiate this process, a certain amount of Ca in the cleft space is necessary. When the membrane potential becomes higher during excitation-contraction coupling, Ca can enter through both Ca current (I(CaL)) and sodium-calcium exchanger (NCX) and may activate ryanodine receptors to initiate a Ca spark. On the other hand, at the resting membrane potential (V(m) ~-80 mV), NCX removes Ca from the cell (forward mode). If Ca released from the sarcoplasmic reticulum is quickly removed via forward mode NCX before Ca-induced Ca release starts, the Ca release becomes nonspark Ca leak. This would also be influenced by the cleft/noncleft distribution of NCX, which is unknown. Using a physiologically detailed mathematical model of subcellular Ca cycling, we analyze how NCX strength and distribution alter Ca spark formation. During excitation-contraction coupling, most Ca sparks are induced by I(CaL) with very few due to NCX current. At the resting membrane potential if most NCX is localized to the cleft, spontaneous Ca sparks are significantly reduced.
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Registered trials
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