ArticleBiophysical journal2012
Molecular structure of membrane tethers.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Review
- Biophysical Interaction Landscape of Mycobacterial Mycolic Acids and Phenolic Glycolipids with Host Macrophage Membranes.ACS applied bio materials · 2023Article
- Molecular Dynamics Simulations of Curved Lipid Membranes.International journal of molecular sciences · 2022Review
- FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes.The journal of physical chemistry letters · 2021Article
- Influence of membrane-cortex linkers on the extrusion of membrane tubes.Biophysical journal · 2021Article
- Surface Shear Viscosity and Interleaflet Friction from Nonequilibrium Simulations of Lipid Bilayers.Journal of chemical theory and computation · 2019Article
- The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol.Nature communications · 2019Article
- Mechanics of the Formation, Interaction, and Evolution of Membrane Tubular Structures.Biophysical journal · 2019Article
- BUMPy: A Model-Independent Tool for Constructing Lipid Bilayers of Varying Curvature and Composition.Journal of chemical theory and computation · 2018Article
- Article
- Incorporation of DDR2 clusters into collagen matrix via integrin-dependent posterior remnant tethering.International journal of biological sciences · 2018Article
- Implicit-solvent dissipative particle dynamics force field based on a four-to-one coarse-grained mapping scheme.PloS one · 2018Article
- Combined optical micromanipulation and interferometric topography (COMMIT).Biomedical optics express · 2016Article
- Quantifying Molecular-Level Cell Adhesion on Electroactive Conducting Polymers using Electrochemical-Single Cell Force Spectroscopy.Scientific reports · 2015Article
- Alchembed: A Computational Method for Incorporating Multiple Proteins into Complex Lipid Geometries.Journal of chemical theory and computation · 2015Article
- The power of coarse graining in biomolecular simulations.Wiley interdisciplinary reviews. Computational molecular science · 2014Article
- Methodologies for the analysis of instantaneous lipid diffusion in MD simulations of large membrane systems.Faraday discussions · 2014Article
- Tubular membrane formation of binary giant unilamellar vesicles composed of cylinder and inverse-cone-shaped lipids.Biophysical journal · 2013Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membrane tethers are nanotubes formed by a lipid bilayer. They play important functional roles in cell biology and provide an experimental window on lipid properties. Tethers have been studied extensively in experiments and described by theoretical models, but their molecular structure remains unknown due to their small diameters and dynamic nature. We used molecular dynamics simulations to obtain molecular-level insight into tether formation. Tethers were pulled from single-component lipid bilayers by application of an external force to a lipid patch along the bilayer normal or by lateral compression of a confined bilayer. Tether development under external force proceeded by viscoelastic protrusion followed by viscous lipid flow. Weak forces below a threshold value produced only a protrusion. Larger forces led to a crossover to tether elongation, which was linear at a constant force. Under lateral compression, tethers formed from undulations of unrestrained bilayer area. We characterized in detail the tether structure and its formation process, and obtained the material properties of the membrane. To our knowledge, these results provide the first molecular view of membrane tethers.
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