ArticleBiophysical journal2012
Physical model for self-organization of actin cytoskeleton and adhesion complexes at the cell front.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Reconstructing Actin Dynamics of the Leading Edge from Observational Data.bioRxiv : the preprint server for biology · 2026Article
- Allometric cell spreading and the geometrical control of focal adhesion collective organization.Biophysical journal · 2025Article
- Modeling cell protrusion predicts how myosin II and actin turnover affect adhesion-based signaling.Biophysical journal · 2022Article
- Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes.PLoS computational biology · 2021Article
- Stick-slip model for actin-driven cell protrusions, cell polarization, and crawling.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics.iScience · 2020Article
- Forces and constraints controlling podosome assembly and disassembly.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Extracellular Matrix Geometry and Initial Adhesive Position Determine Stress Fiber Network Organization during Cell Spreading.Cell reports · 2019Article
- Steps in Mechanotransduction Pathways that Control Cell Morphology.Annual review of physiology · 2019Review
- Predicting Collective Migration of Cell Populations Defined by Varying Repolarization Dynamics.Biophysical journal · 2018Article
- On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility.Molecular biology of the cell · 2018Article
- Buckle up: Membrane tension drives lamellipodial network compression and adhesion deposition.The Journal of cell biology · 2017Article
- Membrane tension controls adhesion positioning at the leading edge of cells.The Journal of cell biology · 2017Article
- Shifting the optimal stiffness for cell migration.Nature communications · 2017Article
- Physical Model for Stabilization and Repair of Trans-endothelial Apertures.Biophysical journal · 2017Article
- Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch.Nature cell biology · 2015Review
- Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge.Physical biology · 2015Article
- Dynamic reorganization of the actin cytoskeleton.F1000Research · 2015Review
- Actin flow and talin dynamics govern rigidity sensing in actin-integrin linkage through talin extension.Journal of the Royal Society, Interface · 2014Article
- Dynamics of cell shape and forces on micropatterned substrates predicted by a cellular Potts model.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell motion is driven by interplay between the actin cytoskeleton and the cell adhesions in the front part of the cell. The actin network segregates into lamellipodium and lamellum, whereas the adhesion complexes are characteristically distributed underneath the actin system. Here, we suggest a computational model for this characteristic organization of the actin-adhesion system. The model is based on the ability of the adhesion complexes to sense mechanical forces, the stick-slip character of the interaction between the adhesions and the moving actin network, and a hypothetical propensity of the actin network to disintegrate upon sufficiently strong stretching stresses. We identify numerically three possible types of system organization, all observed in living cells: two states in which the actin network exhibits segregation into lamellipodium and lamellum, whereas the cell edge either remains stationary or moves, and a state where the actin network does not undergo segregation. The model recovers the asynchronous fluctuations and outward bulging of the cell edge, and the dependence of the edge protrusion velocity on the rate of the nascent adhesion generation, the membrane tension, and the substrate rigidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.