Evidence map›Paper›PMID 22768891›Full record

ArticleJournal of diabetes science and technology2012

Retinal vascular geometry in Asian persons with diabetes and retinopathy.

Carol Yim-lui Cheung, Ecosse Lamoureux, M Kamran Ikram, M Bayu Sasongko, Jie Ding, Yingfeng Zheng, Paul Mitchell, Jie Jin Wang, Tien Yin Wong

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Retinal vessel tortuosity and fractal dimension in diabetic retinopathy.International journal of retina and vitreous · 2025
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  9. Imaging the eye and its relevance to diabetes care.Journal of diabetes investigation · 2021
    Review
  10. Article
  11. Type 2 diabetes and HbADiabetologia · 2020
    Article
  12. Article
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  19. Retinal vascular geometry and its association to microvascular complications in patients with type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017
    Article
  20. Retinal vasculature in glaucoma: a review.BMJ open ophthalmology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Carol Yim-lui CheungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore. carol.cheung.y.l@seri.com.sg
Ecosse Lamoureux
M Kamran Ikram
M Bayu Sasongko
Jie Ding
Yingfeng Zheng
Paul Mitchell
Jie Jin Wang
Tien Yin Wong
National University of Singapore · SGSingapore National Eye Center · SGUniversity of Sydney · AUCentre for Eye Research Australia · AUSingapore Eye Research Institute · SGUniversitas Gadjah Mada · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOur purpose was to examine the relationship of retinal vascular parameters with diabetes and retinopathy in an older Asian population.

methodsRetinal photographs from participants of a population-based survey of Asian Malay persons aged 40-80 years were analyzed. Specific retinal vascular parameters (tortuosity, branching angle, fractal dimension, and caliber) were measured using a semiautomated computer-based program. Diabetes was defined as random plasma glucose ≥ 11.1 mmol/liter, the use of diabetes medication, or physician-diagnosed diabetes. Retinopathy signs were graded from photographs using the modified Airlie House classification system.

resultsA total of 2735 persons were included in the study. Persons with diabetes (n = 594) were more likely to have straighter (less tortuous) arterioles and wider arteriolar and venular caliber than those without diabetes (n = 2141). Among subjects with diabetes, those with retinopathy had wider venular caliber than those without retinopathy (211.3 versus 204.9 mm, p = .001). Among nondiabetic subjects, however, those with retinopathy had more tortuous venules than those without retinopathy [5.19(×10(4)) versus 4.27(×10(4)), p < .001].

conclusionsRetinal vascular parameters varied by diabetes and retinopathy status in this older Asian cohort. Our findings suggest that subtle alterations in retinal vascular architecture are influenced by diabetes.

Indexed as

AdultAgedAged, 80 and overAsian PeopleAutomation, LaboratoryCross-Sectional StudiesDiabetic RetinopathyFemaleHumansImage Interpretation, Computer-AssistedMalaysiaMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsRetinal Vessels

Identifiers

PMID22768891
PMCPMC3440033
OpenAlexW2164023647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.