ReviewJournal of diabetes science and technology2012
The cat as a model for human obesity and diabetes.
Review in Journal of diabetes science and technology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 72 citations in OpenAlex.
- An investigation of feeding instructions on cat food labels in Belgium and comparison with European industry energy intake recommendations.The Veterinary record · 2026Article
- Association of inflammation with glycemic control, insulin sensitivity, and beta-cell function in diabetic cats.Journal of veterinary internal medicine · 2026Article
- From pathogenesis to prevention: an update on the management of obesity and its associated comorbidities in cats.Frontiers in veterinary science · 2026Review
- Transcriptional regulation in skeletal muscle and adipose tissue of lean and obese colony cats.PloS one · 2026Article
- Glucose-Lowering Effects and Safety ofMicroorganisms · 2025Article
- Adipose gene expression related to body condition score and individual variations in hospitalized cats.Scientific reports · 2025Article
- The role of HbA1c in identifying dogs at high risk for diabetes despite normal blood glucose levels.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2025Article
- Metabolic Profiles of Feline Obesity Revealed by Untargeted and Targeted Mass Spectrometry-Based Metabolomics Approaches.Veterinary sciences · 2025Article
- Exploring Gastrointestinal Health in Diabetic Cats: Insights from Owner Surveys, Ultrasound, and Histopathological Analysis.Veterinary sciences · 2025Article
- Characterization of feline nonsteroidal anti-inflammatory drug activated gene-1 (fNAG-1) and its protective function in kidney cells.BMC veterinary research · 2025Article
- Footprint-free induced pluripotent stem cells can be successfully differentiated into mesenchymal stromal cells in the feline model.Stem cell research & therapy · 2025Article
- Sodium-glucose co-transporter 2 inhibitors: a pleiotropic drug in humans with promising results in cats.Frontiers in veterinary science · 2025Review
- Feline Diabetes Is Associated with Deficits in Markers of Insulin Signaling in Peripheral Tissues.International journal of molecular sciences · 2024Article
- Overweight and obesity in domestic cats: epidemiological risk factors and associated pathologies.Journal of feline medicine and surgery · 2024Review
- Differential effects of ganglioside lipids on the conformation and aggregation of islet amyloid polypeptide.Protein science : a publication of the Protein Society · 2024Article
- Body Condition Scores in Cats and Associations with Systolic Blood Pressure, Glucose Homeostasis, and Systemic Inflammation.Veterinary sciences · 2024Article
- Description of the fasted serum metabolomic signature of lean and obese cats at maintenance and of obese cats under energy restriction.PloS one · 2024Article
- Rodent models to study type 1 and type 2 diabetes induced human diabetic nephropathy.Molecular biology reports · 2023Review
- Short-term evaluation of renal markers in overweight adult cats.Veterinary medicine and science · 2023Article
- Short-term changes in dietary fat levels and starch sources affect weight management, glucose and lipid metabolism, and gut microbiota in adult cats.Journal of animal science · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is the most common nutritional disorder of cats and is a risk factor for diabetes. Similar to developments in obese people, obese cats show peripheral tissue insulin resistance and may demonstrate glucose intolerance when challenged with pharmacological amounts of glucose. However, they compensate well for the insulin resistance and do not show elevated glucose concentrations when monitored during their regular daily routine, including postprandial periods. This is possible because obese cats in the fasted and postprandial state are able to maintain hepatic insulin sensitivity and decrease endogenous glucose production, which allows them to maintain normoglycemia. Also dissimilar to what is seen in many obese humans, cats do not develop atherosclerosis and clinical hypertension. The time course for progression to overt diabetes of obese cats is unknown. One might speculate that diabetes develops when the liver finally becomes insulin resistant and/or insulin secretion becomes too low to overcome increased glucose production. In addition, amyloid, demonstrated to be deposited in islet of chronically obese cats, may contribute to a reduction in insulin secretion by reducing functional β-cell mass.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.