ArticleCell metabolism2012
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
Article in Cell metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 77 citations in OpenAlex.
- Application ofBiomolecules & therapeutics · 2026Review
- Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in C. elegans.Nature communications · 2026Article
- Deciphering the regulatory mechanism of neural behavioral decisions through biogenic amine-mediated modulation of neural circuits inFrontiers in systems neuroscience · 2026Review
- Context-dependent serotonin signaling links dietary quality to foraging decisions.Nature communications · 2025Article
- Quantifying Food Intake in Caenorhabditis elegans by Measuring Bacterial Clearance.Journal of visualized experiments : JoVE · 2024Article
- Chronic Stress-induced Serotonin Impairs Intestinal Epithelial Cell Mitochondrial Biogenesis via the AMPK-PGC-1α Axis.International journal of biological sciences · 2024Article
- Application ofInternational journal of molecular sciences · 2023Review
- Insight of Silkworm Pupa Oil Regulating Oxidative Stress and Lipid Metabolism inFoods (Basel, Switzerland) · 2022Article
- Lysosome Inhibition Reduces Basal and Nutrient-Induced Fat Accumulation inMolecules and cells · 2022Article
- Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2022Article
- Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide.PLoS pathogens · 2021Article
- Wired for insight-recent advances in Caenorhabditis elegans neural circuits.Current opinion in neurobiology · 2021Review
- The Prop1-like homeobox geneeLife · 2021Article
- Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans.Development (Cambridge, England) · 2021Article
- Serotonin and Dopamine Mimic Glucose-Induced Reinforcement inFrontiers in physiology · 2021Article
- The bHLH-PAS genemicroPublication biology · 2021Article
- A Multicellular Network Mechanism for Temperature-Robust Food Sensing.Cell reports · 2020Article
- Mitochondrial light switches: optogenetic approaches to control metabolism.The FEBS journal · 2020Review
- Article
- Feeding, hunger, satiety and serotonin in invertebrates.Proceedings. Biological sciences · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Serotonergic regulation of feeding behavior has been studied intensively, both for an understanding of the basic neurocircuitry of energy balance in various organisms and as a therapeutic target for human obesity. However, its underlying molecular mechanisms remain poorly understood. Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcription factor associated with obesity. In turn, glutamatergic signaling links these interneurons to pharyngeal neurons implicated in feeding behavior. We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling.
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