ArticleCell metabolism2012
A role for period 2 in cardioprotection.
Article in Cell metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Diurnal Variation in Melatonin-Mediated Cardiac Protection via Per2 Expression in Heart.Journal of pineal research · 2025Article
- Targeting circadian PER2 as therapy in myocardial ischemia and reperfusion injury.Chronobiology international · 2021Review
- Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium.American journal of physiology. Heart and circulatory physiology · 2013Article
- Attenuating myocardial ischemia by targeting A2B adenosine receptors.Trends in molecular medicine · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How adenosine receptors protect the ischemic heart is not completely understood. Eckle et al. (2012) now show that signaling through adenosine receptor 2b (Adora2b) stabilizes a circadian rhythm protein, period 2 (Per2), resulting in the stabilization of hypoxia-inducible factor-1α (HIF-1α), upregulation of glycolysis, and cardioprotection from ischemia.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.