ArticleScientific reports2012
Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Extracellular vesicle transcriptomic analysis to investigate muscle adaptation in microgravity.iScience · 2026Article
- The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development.Scientific reports · 2026Article
- Defining Microbiome Impact on Host Physiology During Spaceflight Using Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Article
- Hypergravity hinders proper dendritic patterning of a sensory neuron in the nematode Caenorhabditis elegans.Scientific reports · 2025Article
- Effect of Hong Huang Tang on memory enhancement and mitigation of microgravity-induced oxidative stress in C. elegans.Biogerontology · 2025Article
- Insects in outer space: assessing the effects of microgravity on edible and model insect species for spaceflight food system.Frontiers in physiology · 2025Review
- Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism.NPJ microgravity · 2024Review
- Spaceflight Induces Strength Decline inCells · 2023Article
- Review
- Review
- A Compact Imaging Platform for ConductingLife (Basel, Switzerland) · 2023Article
- Article
- Microfluidics-integrated spaceflight hardware for measuring muscle strength of Caenorhabditis elegans on the International Space Station.NPJ microgravity · 2022Article
- Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight.Scientific reports · 2022Article
- Space omics research in Europe: Contributions, geographical distribution and ESA member state funding schemes.iScience · 2022Review
- PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity.Frontiers in cell and developmental biology · 2022Article
- Astronauts well-being and possibly anti-aging improved during long-duration spaceflight.Scientific reports · 2021Article
- Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adultiScience · 2021Article
- Mechanobiological Implications of Cancer Progression in Space.Frontiers in cell and developmental biology · 2021Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are likely related to neuronal or endocrine signaling: acetylcholine receptor, acetylcholine transporter, choline acetyltransferase, rhodopsin-like receptor, glutamate-gated chloride channel, shaker family of potassium channel, and insulin-like peptide. Most of them mediated lifespan control through the key longevity-regulating transcription factors DAF-16 or SKN-1 or through dietary-restriction signaling, singly or in combination. These results suggest that aging in C. elegans is slowed through neuronal and endocrine response to space environmental cues.
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Registered trials
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