ArticlePloS one2012
Transcriptome analysis of the Octopus vulgaris central nervous system.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Invertebrate glial barriers as a model for understanding blood-brain barrier evolution.Fluids and barriers of the CNS · 2025Review
- Insights into Octopus maya cathepsins from metatranscriptome and genome: structure evolutionary relationships and functional role prediction in digestive processes.Biology open · 2025Article
- TeCD: The eccDNA Collection Database for extrachromosomal circular DNA.BMC genomics · 2023Article
- Transcriptome-wide selection and validation of a solid set of reference genes for gene expression studies in the cephalopod molluskFrontiers in molecular neuroscience · 2023Article
- De novo transcriptome reconstruction in aquacultured early life stages of the cephalopod Octopus vulgaris.Scientific data · 2022Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Astrocyte-Endotheliocyte Axis in the Regulation of the Blood-Brain Barrier.Neurochemical research · 2021Article
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
- OctoPartenopin: Identification and Preliminary Characterization of a Novel Antimicrobial Peptide from the Suckers ofMarine drugs · 2020Article
- Global impact of diet and temperature over aquaculture of Octopus vulgaris paralarvae from a transcriptomic approach.Scientific reports · 2019Article
- Transcriptome analysis for identifying possible causes of post-reproductive death of Sepia esculenta based on brain tissue.Genes & genomics · 2019Article
- Article
- Transcriptomic Analysis Reveals Insights on Male Infertility inFrontiers in physiology · 2018Article
- A Novel Approach to Primary Cell Culture forFrontiers in physiology · 2018Article
- Article
- Transcriptomic changes in an animal-bacterial symbiosis under modeled microgravity conditions.Scientific reports · 2017Article
- The Gastric Ganglion ofFrontiers in physiology · 2017Article
- Article
- Transcriptome Sequencing and De Novo Assembly of Golden Cuttlefish Sepia esculenta Hoyle.International journal of molecular sciences · 2016Article
- Analyses of Sox-B and Sox-E Family Genes in the Cephalopod Sepia officinalis: Revealing the Conserved and the Unusual.PloS one · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCephalopoda are a class of Mollusca species found in all the world's oceans. They are an important model organism in neurobiology. Unfortunately, the lack of neuronal molecular sequences, such as ESTs, transcriptomic or genomic information, has limited the development of molecular neurobiology research in this unique model organism.
resultsWith high-throughput Illumina Solexa sequencing technology, we have generated 59,859 high quality sequences from 12,918,391 paired-end reads. Using BLASTx/BLASTn, 12,227 contigs have blast hits in the Swissprot, NR protein database and NT nucleotide database with E-value cutoff 1e(-5). The comparison between the Octopus vulgaris central nervous system (CNS) library and the Aplysia californica/Lymnaea stagnalis CNS ESTs library yielded 5.93%/13.45% of O. vulgaris sequences with significant matches (1e(-5)) using BLASTn/tBLASTx. Meanwhile the hit percentage of the recently published Schistocerca gregaria, Tilapia or Hirudo medicinalis CNS library to the O. vulgaris CNS library is 21.03%-46.19%. We constructed the Phylogenetic tree using two genes related to CNS function, Synaptotagmin-7 and Synaptophysin. Lastly, we demonstrated that O. vulgaris may have a vertebrate-like Blood-Brain Barrier based on bioinformatic analysis.
conclusionThis study provides a mass of molecular information that will contribute to further molecular biology research on O. vulgaris. In our presentation of the first CNS transcriptome analysis of O. vulgaris, we hope to accelerate the study of functional molecular neurobiology and comparative evolutionary biology.
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