ArticlePloS one2012
Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Glomerular Injury Induced by Daily Exposure to the Low-Frequency Component of Environmental Noise via Endothelin Signaling in Mice.Environmental science & technology · 2026Article
- Noise-induced vestibular dysfunction in rats: longitudinal assessment using cVEMP and behavioral testing after low-frequency acoustic trauma.Frontiers in integrative neuroscience · 2025Article
- Wind farm noise negatively impacts the calling behavior of three frogs in Caatinga dry forests.PloS one · 2025Article
- An Exploratory Study of Peripheral Vestibular System in Users of Personal Listening Devices.Journal of audiology & otology · 2025Article
- Just 1-min exposure to a pure tone at 100 Hz with daily exposable sound pressure levels may improve motion sickness.Environmental health and preventive medicine · 2025Article
- Characterization of 3,3'-iminodipropionitrile (IDPN) damaged utricle transcriptome in the adult mouse utricle.Frontiers in molecular neuroscience · 2024Article
- Interaction of Hearing and Balance.Laryngo- rhino- otologie · 2023Article
- Noise-Induced Hearing Loss.Journal of clinical medicine · 2023Review
- Peripheral vestibular loss in noise-exposed firefighters.Frontiers in integrative neuroscience · 2023Article
- Balance beam crossing times are slower after noise exposure in rats.Frontiers in integrative neuroscience · 2023Article
- Subtle alterations of vestibulomotor functioning in conductive hearing loss.Frontiers in neuroscience · 2023Article
- A reliable and reproducible protocol for sound-evoked vestibular myogenic potentials in rattus norvegicus.Frontiers in integrative neuroscience · 2023Article
- Article
- Transient peripheral vestibular hypofunction measured with vestibular short-latency evoked potentials following noise exposure in rats.Journal of neurophysiology · 2021Article
- Natural Frequencies Identification by FEM Applied to a 2-DOF Planar Robot and Its Validation Using MUSIC Algorithm.Sensors (Basel, Switzerland) · 2021Article
- Intense noise exposure alters peripheral vestibular structures and physiology.Journal of neurophysiology · 2020Article
- Influence of the NICU on the Acoustic Isolation of a Neonatal Incubator.Frontiers in pediatrics · 2020Article
- Effects of Noise Exposure on the Vestibular System: A Systematic Review.Frontiers in neurology · 2020Review
- Effects of co-exposure to CSJournal of occupational medicine and toxicology (London, England) · 2020Article
- Exposure of Developing Male Rats to One or Multiple Noise Sessions and Different Housing Conditions: Hippocampal Thioredoxin Changes and Behavioral Alterations.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60-70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10-20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.