ArticlePloS one2012
Evolutionary responses to a constructed niche: ancient Mesoamericans as a model of gene-culture coevolution.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Genetic insights into the peoples who shaped the American continent.Genetics and molecular biology · 2026Article
- Genetic and genomic insights of the Comcáac people.Journal of community genetics · 2025Review
- Biogeographic Perspectives on Human Genetic Diversification.Molecular biology and evolution · 2024Article
- Genetic associations with disease in populations with Indigenous American ancestries.Genetics and molecular biology · 2024Article
- Indigenous people from Amazon show genetic signatures of pathogen-driven selection.Science advances · 2023Article
- Genetic etiology of non-syndromic hearing loss in Latin America.Human genetics · 2022Review
- A genomic perspective on South American human history.Genetics and molecular biology · 2022Article
- Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon.Genetics and molecular biology · 2022Article
- Article
- Remembering the past - studies on evolution done by the genetics group at Universidade Federal do Rio Grande do Sul (UFRGS).Genetics and molecular biology · 2018Article
- We're on a road to nowhere: Culture and adaptation to the environment are driving human evolution, but the destination of this journey is unpredictable.EMBO reports · 2017Article
- Tailoring Nutritional Advice for Mexicans Based on Prevalence Profiles of Diet-Related Adaptive Gene Polymorphisms.Journal of personalized medicine · 2017Article
- Genetic signature of natural selection in first Americans.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- NAT2 gene diversity and its evolutionary trajectory in the Americas.The pharmacogenomics journal · 2016Article
- Experimental evidence for the co-evolution of hominin tool-making teaching and language.Nature communications · 2015Article
- Revisiting the Diego Blood Group System in Amerindians: Evidence for Gene-Culture Comigration.PloS one · 2015Article
- An Evolutionary Perspective of Nutrition and Inflammation as Mechanisms of Cardiovascular Disease.International journal of evolutionary biology · 2015Review
- Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes.PloS one · 2015Article
- Detection of convergent genome-wide signals of adaptation to tropical forests in humans.PloS one · 2015Article
- Differing evolutionary histories of the ACTN3*R577X polymorphism among the major human geographic groups.PloS one · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Culture and genetics rely on two distinct but not isolated transmission systems. Cultural processes may change the human selective environment and thereby affect which individuals survive and reproduce. Here, we evaluated whether the modes of subsistence in Native American populations and the frequencies of the ABCA1*Arg230Cys polymorphism were correlated. Further, we examined whether the evolutionary consequences of the agriculturally constructed niche in Mesoamerica could be considered as a gene-culture coevolution model. For this purpose, we genotyped 229 individuals affiliated with 19 Native American populations and added data for 41 other Native American groups (n = 1905) to the analysis. In combination with the SNP cluster of a neutral region, this dataset was then used to unravel the scenario involved in 230Cys evolutionary history. The estimated age of 230Cys is compatible with its origin occurring in the American continent. The correlation of its frequencies with the archeological data on Zea pollen in Mesoamerica/Central America, the neutral coalescent simulations, and the F(ST)-based natural selection analysis suggest that maize domestication was the driving force in the increase in the frequencies of 230Cys in this region. These results may represent the first example of a gene-culture coevolution involving an autochthonous American allele.
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