ArticleThe Journal of clinical endocrinology and metabolism2012
Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging.
Article in The Journal of clinical endocrinology and metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The trial behind it
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Who cites it
43 citing papers in PubMed, 92 citations in OpenAlex.
- Trial
- Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study.Nutrition & diabetes · 2022Trial
- Trial
- The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes.The Korean journal of internal medicine · 2014Trial
- Commentary on "The Association of Circulating Bone Morphogenetic Protein 9 and Arterial Stiffness in Hypertensive Patients".Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Coronary Artery Calcium Is Independently Associated with Arterial Stiffness and LDL Cholesterol Burden in Patients with Familial Hypercholesterolemia.Journal of clinical medicine · 2025Article
- Subclinical Carotid Disease Is Associated with Low Serum Vitamin D in Nondiabetic Middle-Aged Hypertensive Patients.Nutrients · 2025Article
- The relationship between the level of vitamin D and ruptured intracranial aneurysms among patients with high sun exposure.Scientific reports · 2024Article
- Can we reverse arterial stiffness by intervening on CKD-MBD biomarkers?Clinical kidney journal · 2023Review
- Correlation between Serum 25-Hydroxyvitamin D Level and Peripheral Arterial Stiffness in Chronic Kidney Disease Stage 3-5 Patients.Nutrients · 2022Article
- Relationships between Vitamin D and Selected Cytokines and Hemogram Parameters in Professional Football Players-Pilot Study.International journal of environmental research and public health · 2021Article
- The relationship between the level of vitamin D and ruptured intracranial aneurysms.Scientific reports · 2021Article
- Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels.Journal of clinical medicine · 2020Article
- A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging.Journal of internal medicine · 2020Article
- The associations of vitamin D status and dietary calcium with the metabolic syndrome: an analysis of the Victorian Health Monitor survey.Public health nutrition · 2017Article
- Association of Serum 25-hydroxy-vitamin D Concentration and Arterial Stiffness among Korean Adults in Single Center.Journal of bone metabolism · 2017Article
- Impact of seasonality and air pollutants on carotid-femoral pulse wave velocity and wave reflection in hypertensive patients.PloS one · 2017Article
- Effectiveness of Vitamin D Supplementation for Cardiovascular Health Outcomes.Pulse (Basel, Switzerland) · 2017Review
- Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients.Journal of diabetes research · 2017Article
- Association of serum vitamin D and parathyroid hormone with subclinical atherosclerotic phenotypes: The Dong-gu Study.PloS one · 2017Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
contextThe importance of vitamin D for bone health has long been acknowledged. Recent evidence suggests that vitamin D can also play a role in reducing the risk of several other diseases, including cardiovascular disease.
objectiveThe aim of this study is to test the hypothesis that 25-hydroxyvitamin D (25-OH D) is an independent cross-sectional correlate of central arterial stiffness in a normative aging study population. DESIGN AND SETTINGS: We conducted a cross-sectional analysis. SUBJECTS: We studied 1228 healthy volunteers (50% males; age, 70±12 yr) of the Baltimore Longitudinal Study of Aging.
main outcome measuresWe measured carotid-femoral pulse wave velocity (PWV) and 25-OH D levels.
resultsWe found a significant inverse association between PWV and 25-OH D levels (adjusted r2=0.27; β=-0.43; P=0.001). After adjusting for age, gender, ethnicity, season of blood draw, estimated glomerular filtration rate, physical activity level, cardiovascular risk factors score (smoking, visceral obesity, hypercholesterolemia, hypertension, and diabetes), calcium/vitamin D supplementation, serum calcium, and PTH levels, the association between PWV and 25-OH D levels was only slightly reduced and remained statistically significant (adjusted r2=0.34; β=-0.34; P=0.04).
conclusionsVitamin D levels are inversely associated with increased arterial stiffness in a normative aging population, irrespective of traditional risk factor burden. Further research is needed to understand the mechanism of this association and to test the hypothesis that vitamin D supplementation can reduce arterial stiffness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.