Evidence map›Paper›PMID 22767316›Full record

ArticleJournal of cancer research and clinical oncology2012

Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph.

Nikolaus Becker, Paul Schnitzler, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadié, Alexandra Nieters, Anthony Staines, Yolanda Benavente, Pierluigi Cocco and 1 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  19. High prevalence of hepatitis B virus infection in primary central nervous system lymphoma.International journal of clinical and experimental medicine · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 7 countries.

Nikolaus BeckerDivision of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. n.becker@dkfz.de
Paul Schnitzler
Paolo Boffetta
Paul Brennan
Lenka Foretova
Marc Maynadié
Alexandra Nieters
Anthony Staines
Yolanda Benavente
Pierluigi Cocco
Silvia de Sanjose
Heidelberg University · DECentre Hospitalier Universitaire Dijon Bourgogne · FRCentre International de Recherche sur le Cancer · FRCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESDublin City University · IEGerman Cancer Research Center · DEInstitut d'Investigació Biomédica de Bellvitge · ESInternational Prevention Research Institute · FRMasaryk Memorial Cancer Institute · CZUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe have recently reported from Epilymph, a multicentre case-control study of lymphoma conducted in six European countries, a significant association between NHL and self-reported history of past or present HBV infection based on questionnaire data from face-to-face interviews.

methodsTo corroborate this observation, we used the data and blood specimen from Epilymph to investigate the associations between serological indicators of HBV infection with risk of Hodgkin lymphoma, non-Hodgkin lymphoma (NHL) and specific lymphoma entities. For 1,518 cases and 1,496 controls with sufficient amount of serum or plasma, we tested HBs-antigen, anti-HBc and anti-HBs to distinguish between current or past infection and immunity by vaccination. Statistical analysis was carried out with unconditional logistic regression.

resultsWe found a positive association of a past HBV infection with multiple myeloma (MM, OR = 1.97, 95 % CL = 1.16-3.37). Non-significant associations were found between past HBV infection and B-cell chronic lymphocytic leukaemia (B-CLL, OR = 1.33, 95 % CL = 0.82-2.16) and T-cell NHL (OR = 1.59, 95 % CL = 0.65-3.90), as well as between current HBV infection and NHL (OR = 1.49, 95 % CL = 0.65-3.41), B-NHL (OR = 1.58, 95 % CL = 0.69-3.64) and diffuse large B-cell lymphoma (DLBCL, OR = 1.50, 95 % CL = 0.47-4.82). Subjects having self-reported HBV infection were serological positive in 75 % of cases and 80 % of controls. For vaccination, the corresponding figures were 49 and 54 %, respectively.

conclusionThe present results support previous reports of an association between a history of HBV infection with an elevated lymphoma risk and add multiple myeloma to the list of potentially virus-associated lymphoma entities.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesEuropeFemaleHepatitis BHepatitis B Surface AntigensHepatitis B virusHodgkin DiseaseHumansLeukemia, Lymphocytic, Chronic, B-CellLymphoma, Non-HodgkinMaleMiddle AgedMultiple MyelomaHepatitis B Surface Antigens

Identifiers

PMID22767316
PMCPMC11824685
OpenAlexW2031730698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.