Evidence map›Paper›PMID 22767203›Full record

SynthesisJournal of the National Cancer Institute2012

Meta-analysis of efficacy of interventions for elevated depressive symptoms in adults diagnosed with cancer.

Stacey L Hart, Michael A Hoyt, Michael Diefenbach, Derek R Anderson, Kristin M Kilbourn, Lynette L Craft, Jennifer L Steel, Pim Cuijpers, David C Mohr, Mark Berendsen and 2 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the National Cancer Institute, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 18 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 18 syntheses or guidelines pooled it, 201 citations in OpenAlex.

  1. Pooled it
  2. Effectiveness of creative arts therapy for adult patients with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  3. Systematic review and meta-analysis of the effectiveness of expressive writing disclosure on cancer and palliative care patients' health-related outcomes.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
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  9. A systematic review of psychological interventions for patients with head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  10. Antidepressants for the treatment of depression in people with cancer.The Cochrane database of systematic reviews · 2018
    Pooled it
  11. Psychological interventions for acute pain after open heart surgery.The Cochrane database of systematic reviews · 2017
    Pooled it
  12. A systematic review of psychosocial interventions for colorectal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Pooled it
  13. Pooled it
  14. Antidepressants for the treatment of depression in people with cancer.The Cochrane database of systematic reviews · 2015
    Pooled it
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  16. Guideline
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  19. Trial
  20. Trial

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Stacey L HartDepartment of Psychology, University of California Los Angeles, CA 90095-1563, USA.
Michael A Hoyt
Michael Diefenbach
Derek R Anderson
Kristin M Kilbourn
Lynette L Craft
Jennifer L Steel
Pim Cuijpers
David C Mohr
Mark Berendsen
Bonnie Spring
Annette L Stanton
University of California, Los Angeles · US

Funding

MULTIDISCIPLINARY CLINICAL AND TRANSLATIONAL SCIENCE (MCTS) PROGRAM (UL1)UL1RR025741 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GREENLAND, PHILIP · 2008 to 2011
$24.7M
Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)UL1TR000150 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$10.1M
Emotion Regulation and Depression in Breast Cancer SurvivorshipR01CA133081 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STANTON, ANNETTE L, WEIHS, KAREN L. · 2009 to 2014
$2.9M
Comprehensive Electronic Support System for Treatment of Cancer-Related SymptomsK07CA118576 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEEL, JENNIFER L. · 2006 to 2010
$757k
Intermittent Exercise and Symptom Management in Breast Cancer SurvivorsK07CA134936 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CRAFT, LYNETTE L · 2009 to 2011
$397k
NCATS NIH HHS UL1 TR000150NCI NIH HHS 1R01CA133081NCI NIH HHS 5K07CA118576-02NCI NIH HHS 5K07CA134936-03NCI NIH HHS K07 CA118576NCI NIH HHS K07 CA134936NCI NIH HHS R01 CA133081NCRR NIH HHS UL1 RR025741
6 · The paper itself

Abstract

backgroundCancer patients are at increased risk for depression compared with individuals with no cancer diagnosis, yet few interventions target depressed cancer patients.

methodsEfficacy of psychotherapeutic and pharmacologic interventions for depression in cancer patients who met an entry threshold for depressive symptoms was examined by meta-analysis. Five electronic databases were systematically reviewed to identify randomized controlled trials meeting the selection criteria. Effect sizes were calculated using Hedges' g and were pooled to compare pre- and postrandomization depressive symptoms with a random effects model. Subgroup analyses tested moderators of effect sizes, such as comparison of different intervention modalities, with a mixed effects model. All statistical tests were two-sided.

resultsTen randomized controlled trials (six psychotherapeutic and four pharmacologic studies) met the selection criteria; 1362 participants with mixed cancer types and stages had been randomly assigned to treatment groups. One outlier trial was removed from analyses. The random effects model showed interventions to be superior to control conditions on reducing depressive symptoms postintervention (Hedges' g = 0.43, 95% confidence interval = 0.30 to 0.56, P < .001). In the four psychotherapeutic trials with follow-up assessment, interventions were more effective than control conditions up to 12-18 months after patients were randomly assigned to treatment groups (P < .001). Although each approach was more effective than the control conditions in improving depressive symptoms (P < .001), subgroup analyses showed that cognitive behavioral therapy appeared more effective than problem-solving therapy (P = .01), but not more effective than pharmacologic intervention (P = .07).

conclusionsOur findings suggest that psychological and pharmacologic approaches can be targeted productively toward cancer patients with elevated depressive symptoms. Research is needed to maximize effectiveness, accessibility, and integration into clinical care of interventions for depressed cancer patients.

Indexed as

Adaptation, PsychologicalCognitive Behavioral TherapyProblem SolvingAdultAntidepressive AgentsConfounding Factors, EpidemiologicDatabases, FactualDepressionHumansMajor Depressive DisorderNeoplasmsPublication BiasRandomized Controlled Trials as TopicRisk FactorsSeverity of Illness IndexStress, PsychologicalAntidepressive Agents

Identifiers

PMID22767203
PMCPMC3634552
OpenAlexW2161058613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.