Evidence map›Paper›PMID 22767056›Full record

ArticleChemical immunology and allergy2012

Stress-related programming of autonomic imbalance: role in allergy and asthma.

Rosalind J Wright

Open access · bronzeAbstract read
In one paragraph

Article in Chemical immunology and allergy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Neonatal rhinorrhea, heart rate variability, and childhood exercise-induced wheeze.The journal of allergy and clinical immunology. Global · 2023
    Article
  3. Association between constipation and the development of asthma: a meta-analysis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
    Article
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  15. Article
  16. Article
  17. Stress and obesity as risk factors in cardiovascular diseases: a neuroimmune perspective.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Rosalind J WrightChanning Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. rosalind.wright@channing.harvard.edu
Brigham and Women's Hospital · US

Funding

Stress, Environment, and Genetics in Urban AsthmaR01HL080674 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROSALIND J · 2005 to 2014
$7.0M
Perinatal Programming of Infant Stress Reactivity and the Atopic PhenotypeR01HL095606 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOSQUET ENLOW, MICHELLE A, WRIGHT, ROSALIND J · 2010 to 2013
$3.1M
NHLBI NIH HHS R01 HL080674NHLBI NIH HHS R01HL080674NHLBI NIH HHS R01 HL095606NHLBI NIH HHS R01HL095606
6 · The paper itself

Abstract

Evidence linking psychological stress to allergy has grown with our increased understanding of the natural history and pathophysiology of these disorders and the neurobiology of stress vulnerability. However, the specific pathways that increase vulnerability to developing allergy and associated disorders remain to be elucidated. Autonomic nervous system functioning (autonomic balance) has been implicated in allergy for some time albeit links between autonomic balance and immune function in early development have been under studied. Starting in utero, stress may influence the programming of brain neurotransmitter systems, sympathetic and parasympathetic nervous system functioning, and the hypothalamic-pituitary-adrenal axis, which in turn may alter neural regulation of immune function. Epigenetic dysregulation of gene expression may be a fundamental mechanism for programming of early neural-immune processes.

Indexed as

Stress, PhysiologicalStress, PsychologicalAdrenal CortexAsthmaAutonomic Nervous SystemBrainEpigenesis, GeneticFemaleHumansHypothalamusImmunomodulationPituitary GlandPregnancy

Identifiers

PMID22767056
PMCPMC3888825
OpenAlexW1846433940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.