ArticleHerz2012
Interleukin-6 and E-selectin in acute coronary syndromes and stable angina pectoris. A comparative study.
Article in Herz, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study.European stroke journal · 2026Article
- Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study.European stroke journal · 2025Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of the study was to compare the serum levels of interleukin-6 (IL-6), E-selectin, and trans-fatty acids (TFA) between those with stable and unstable angina pectoris.
methodsFrom September 2008 to March 2009, a case-control study was performed at two university hospitals. We included 89 patients with acute coronary syndrome (ACS) including patients with myocardial infarction and those with unstable angina pectoris (case group) and 93 patients with stable angina pectoris (control group). The two groups were matched with respect to demographic characteristics and risk factors of cardiovascular diseases. Serum levels of IL-6 and E-selectin were measured using the enzyme linked immunosorbent assay, while TFA and lipoproteins were measured using gas chromatography and enzymatic methods, respectively.
resultsNo significant differences between baseline characteristics of the two study groups were observed. Patients with stable angina had significantly higher serum levels of total cholesterol (187.0 ± 3.7 vs. 171.6 ± 4.2 mg/dl; p = 0.009), low density lipoproteins (104.8 ± 2.4 vs. 95.4 ± 2.7; p = 0.017), and TFA (1.41 ± 0.47 vs. 1.24 ± 0.69 mg/dl; p = 0.047) compared to those with ACS. Serum levels of IL-6 were found to be significantly higher in those with stable angina compared to those with ACS (102.4 ± 1.9 vs. 224.6 ± 3.6; p = 0.007). However, patients with ACS had higher levels of E-selectin (53.5 ± 25.7 vs. 49.2 ± 23.5 µg/dl; p = 0.52), but the difference did not reach statistical significance.
conclusionIn the current study, inflammation as measured by IL-6 and E-selectin was not found to play an important role in progression of ischemic heart disease from stable angina to unstable angina or myocardial infarction, which is contrary to previous studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.