Evidence map›Paper›PMID 22766301›Full record

ArticleColloids and surfaces. B, Biointerfaces2012

Effect of viscous drag on multiple receptor-ligand bonds rupture force.

V K Gupta

Abstract read
In one paragraph

Article in Colloids and surfaces. B, Biointerfaces, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds.The European physical journal. E, Soft matter · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

V K GuptaUniversity of Maryland Baltimore County, Baltimore, MD 21250, USA. vkg@umbc.edu

Funding

Computational model of cellular adhesion in bulk flowsR01AI063366 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI EGGLETON, CHARLES DIONISIO · 2005 to 2009
$1.5M
NIAID NIH HHS R01 AI063366
6 · The paper itself

Abstract

Monte Carlo simulation of the rupture of multiple receptor-ligand bonds between two PMN cells suspended in a Newtonian fluid is performed. We demonstrate via micro-mechanical model of two cells adhered by multiple receptor-ligand bonds that viscous drag caused by relative motion of cell suspended in a Newtonian fluid modulates transmission of an applied external load to bonds. Specifically, it is demonstrated that at any time the intermolecular bond force is not equivalent to the instantaneous applied force. The difference in the instantaneous applied force and the intermolecular bond force depends on the viscosity of fluid, the size of cell, the applied loading rate, and the number of bonds at any instant of time. Viscous drag acting on cell reduces average bond rupture forces.

Indexed as

Models, BiologicalCell CommunicationCell SizeComputer SimulationFrictionHumansLigandsMonte Carlo MethodNeutrophilsProtein BindingReceptors, Cell SurfaceViscosityLigandsReceptors, Cell Surface

Identifiers

PMID22766301
PMCPMC3404210

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.