Evidence map›Paper›PMID 22766217›Full record

ArticleBioorganic & medicinal chemistry2012

Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα.

Paul Klausmeyer, Thomas G McCloud, Dominic A Scudiero, Michael J Currens, John H Cardellina Ii, Robert H Shoemaker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Paul KlausmeyerNatural Products Support Group, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702-1201, USA. klausmeyerp@mail.nih.gov
Thomas G McCloud
Dominic A Scudiero
Michael J Currens
John H Cardellina Ii
Robert H Shoemaker
Frederick National Laboratory for Cancer Research · USScience Applications International Corporation (United States) · US

Funding

NCI NIH HHS N01 CO012400NCI NIH HHS N01-CO-12400
6 · The paper itself

Abstract

A high throughput in vitro screen has been developed to identify substances that induce expression of C/EBPα in tumor cells. An extract of the fruit of Gyrocarpus jacquinii showed induction of C/EBPα activity that was attributed to the bisbenzylisoquinoline (BBIQ) alkaloid pheanthine (13) by dereplication analysis. The research project was broadened to assess the effect of other natural BBIQ structural types occurring outside the genus Gyrocarpus. Several of the 28 compounds assayed showed enhancement of C/EBPα induction in U937 cells. The results of this study should encourage future efforts toward obtaining and screening a larger set of both natural and synthetic analogs of this interesting group of alkaloids.

Indexed as

Drug DiscoveryAntineoplastic AgentsBenzylisoquinolinesCCAAT-Enhancer-Binding Protein-alphaCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorFruitHernandiaceaeHigh-Throughput Screening AssaysHumansMolecular StructurePlant ExtractsStereoisomerismStructure-Activity RelationshipU937 CellsAntineoplastic AgentsBenzylisoquinolinesCCAAT-Enhancer-Binding Protein-alphaPlant Extracts

Identifiers

PMID22766217
PMCPMC3430122
OpenAlexW2016697609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.