ReviewExperimental neurology2013
Neuroanatomy of the extended circadian rhythm system.
Review in Experimental neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
139 citing papers in PubMed, 1 synthesis or guideline pooled it, 310 citations in OpenAlex.
- Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders.Frontiers in behavioral neuroscience · 2021Pooled it
- Defining Clock Neurons Within Distributed Circadian Circuits Through Multiscale Technologies.Journal of biological rhythms · 2026Review
- Clocks slide rather than freeze during torpor in the mouse.iScience · 2026Article
- Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network.Neurobiology of sleep and circadian rhythms · 2026Article
- A GABAergic neural circuit from the suprachiasmatic nucleus to DG drives cognitive impairment in migraine mice.The journal of headache and pain · 2026Article
- Synaptic output from suprachiasmatic nucleus cholecystokinin neurons regulates locomotor rhythmicity.Frontiers in neuroscience · 2026Article
- The Novel Functions of M4 Muscarinic Receptors.Physiological research · 2025Review
- Review
- A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Biological Fluid Flows: Signaling Mediums for Circadian Timing.Journal of biological rhythms · 2025Review
- Light, Sound, and Melatonin: Investigating Multisensory Pathways for Visual Restoration.Medicina (Kaunas, Lithuania) · 2025Review
- Early-Life Ventral Hippocampal Lesion and Circadian Disruption Result in Altered Behavior in Adult Mice in a Sex-Dependent Manner.The European journal of neuroscience · 2025Article
- Visible Exocytosis of the Non-Photic Signal Neuropeptide Y to the Suprachiasmatic Nucleus in Fasted Transgenic Mice Throughout Their Circadian Rhythms.Bioengineering (Basel, Switzerland) · 2025Article
- Mettl3-mCell discovery · 2025Article
- Incorporating Physical Activity in a New Two-Oscillator Model of Circadian Activity in Nocturnal and Diurnal Mammals.Journal of biological rhythms · 2025Article
- Light-eye-body axis: exploring the network from retinal illumination to systemic regulation.Theranostics · 2025Review
- Striatal MFrontiers in pharmacology · 2025Article
- The analgesic effect of green light on neuropathic pain: a mini-review of the literature and a proposal for future work.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Circadian rhythms revealed: unraveling the genetic, physiological, and behavioral tapestry of the human biological clock and rhythms.Frontiers in sleep · 2025Review
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The suprachiasmatic nucleus (SCN), site of the primary clock in the circadian rhythm system, has three major afferent connections. The most important consists of a retinohypothalamic projection through which photic information, received by classical rod/cone photoreceptors and intrinsically photoreceptive retinal ganglion cells, gains access to the clock. This information influences phase and period of circadian rhythms. The two other robust afferent projections are the median raphe serotonergic pathway and the geniculohypothalamic (GHT), NPY-containing pathway from the thalamic intergeniculate leaflet (IGL). Beyond this simple framework, the number of anatomical routes that could theoretically be involved in rhythm regulation is enormous, with the SCN projecting to 15 regions and being directly innervated by about 35. If multisynaptic afferents to the SCN are included, the number expands to approximately brain 85 areas providing input to the SCN. The IGL, a known contributor to circadian rhythm regulation, has a still greater level of complexity. This nucleus connects abundantly throughout the brain (to approximately 100 regions) by pathways that are largely bilateral and reciprocal. Few of these sites have been evaluated for their contributions to circadian rhythm regulation, although most have a theoretical possibility of doing so via the GHT. The anatomy of IGL connections suggests that one of its functions may be regulation of eye movements during sleep. Together, neural circuits of the SCN and IGL are complex and interconnected. As yet, few have been tested with respect to their involvement in rhythm regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.