Evidence map›Paper›PMID 22766037›Full record

ReviewBiochimica et biophysica acta

Dynamic regulation of mitochondrial transcription as a mechanism of cellular adaptation.

Erik S Blomain, Steven B McMahon

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Metatranscriptomic reconstruction reveals RNA viruses with the potential to shape carbon cycling in soil.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Erik S BlomainDepartment of Cancer Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19104, USA.
Steven B McMahon

Funding

Functional analysis of transcriptional program regulated by the c-MYC oncoproteinR01CA090465 · NCI · WISTAR INSTITUTE · PI MCMAHON, STEVEN B. · 2002 to 2012
$2.9M
Role of the mitochondrial RNA polymerase POLRMT in MYC functionR01CA141070 · NCI · THOMAS JEFFERSON UNIVERSITY · PI MCMAHON, STEVEN B. · 2011 to 2015
$1.4M
NCI NIH HHS R01 CA090465NCI NIH HHS R01CA090465NCI NIH HHS R01 CA141070NCI NIH HHS R01CA141070
6 · The paper itself

Abstract

Eukaryotes control nearly every cellular process in part by modulating the transcription of genes encoded by their nuclear genome. However, these cells are faced with the added complexity of possessing a second genome, within the mitochondria, which encodes critical components of several essential processes, including energy metabolism and macromolecule biosynthesis. As these cellular processes require gene products encoded by both genomes, cells have adopted strategies for linking mitochondrial gene expression to nuclear gene expression and other dynamic cellular events. Here we discuss examples of several mechanisms that have been identified, by which eukaryotic cells link extramitochondrial signals to dynamic alterations in mitochondrial transcription. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.

Indexed as

MitochondriaTranscription, GeneticAdaptation, BiologicalDNA-Directed RNA PolymerasesDNA, MitochondrialGene Expression RegulationHumansNuclear ProteinsOncogene Protein p55(v-myc)Repressor ProteinsSteroidsDNA-Directed RNA PolymerasesDNA, MitochondrialNKRF protein, humanNuclear ProteinsOncogene Protein p55(v-myc)POLRMT protein, humanRepressor ProteinsRNA polymerase alpha subunitSteroids

Identifiers

PMID22766037
PMCPMC6730671

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.