ArticleStem cells and development2012
TGFβ-dependent epithelial-to-mesenchymal transition is required to generate cardiospheres from human adult heart biopsies.
Article in Stem cells and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Conserved stromal EMT program controls regenerative capacity of mesenchymal stromal cells across multiple tissues.Science advances · 2026Article
- miR-200c-3p Regulates Epitelial-to-Mesenchymal Transition in Epicardial Mesothelial Cells by Targeting Epicardial Follistatin-Related Protein 1.International journal of molecular sciences · 2021Article
- Characterization of human cardiac mesenchymal stromal cells and their extracellular vesicles comparing with human bone marrow derived mesenchymal stem cells.BMB reports · 2020Article
- Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart.Disease models & mechanisms · 2018Article
- Shift of EMT gradient in 3D spheroid MSCs for activation of mesenchymal niche function.Scientific reports · 2017Article
- EMT/MET at the Crossroad of Stemness, Regeneration and Oncogenesis: The Ying-Yang Equilibrium Recapitulated in Cell Spheroids.Cancers · 2017Review
- Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up.Journal of cardiovascular translational research · 2017Review
- Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells with Distinctive Paracrine and Plasticity Properties.Stem cells translational medicine · 2017Article
- Sex Differences of Human Cardiac Progenitor Cells in the Biological Response to TNF-Stem cells international · 2017Article
- Cardiac Progenitor Cells and the Interplay with Their Microenvironment.Stem cells international · 2017Review
- Β-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells.Scientific reports · 2016Article
- Developmental origin and lineage plasticity of endogenous cardiac stem cells.Development (Cambridge, England) · 2016Review
- Foetal bovine serum-derived exosomes affect yield and phenotype of human cardiac progenitor cell culture.BioImpacts : BI · 2016Article
- Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment.Stem cells international · 2016Review
- Generation of cardiac progenitor cells through epicardial to mesenchymal transition.Journal of molecular medicine (Berlin, Germany) · 2015Review
- The potential of GMP-compliant platelet lysate to induce a permissive state for cardiovascular transdifferentiation in human mediastinal adipose tissue-derived mesenchymal stem cells.BioMed research international · 2015Article
- THY-1 receptor expression differentiates cardiosphere-derived cells with divergent cardiogenic differentiation potential.Stem cell reports · 2014Article
- Serum and supplement optimization for EU GMP-compliance in cardiospheres cell culture.Journal of cellular and molecular medicine · 2014Article
- Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function.Frontiers in physiology · 2014Review
- Natural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines.Circulation. Cardiovascular genetics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Autologous cardiac progenitor cells (CPCs) isolated as cardiospheres (CSps) represent a promising candidate for cardiac regenerative therapy. A better understanding of the origin and mechanisms underlying human CSps formation and maturation is undoubtedly required to enhance their cardiomyogenic potential. Epithelial-to-mesenchymal transition (EMT) is a key morphogenetic process that is implicated in the acquisition of stem cell-like properties in different adult tissues, and it is activated in the epicardium after ischemic injury to the heart. We investigated whether EMT is involved in the formation and differentiation of human CSps, revealing that an up-regulation of the expression of EMT-related genes accompanies CSps formation that is relative to primary explant-derived cells and CSp-derived cells grown in a monolayer. EMT and CSps formation is enhanced in the presence of transforming growth factor β1 (TGFβ1) and drastically blocked by the type I TGFβ-receptor inhibitor SB431452, indicating that TGFβ-dependent EMT is essential for the formation of these niche-like 3D-multicellular clusters. Since TGFβ is activated in the myocardium in response to injury, our data suggest that CSps formation mimics an adaptive mechanism that could potentially be enhanced to increase in vivo or ex vivo regenerative potential of adult CPCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.