ArticleEthnicity & disease2012
Gene-environment effects of SLC4A5 and skin color on blood pressure among African American women.
Article in Ethnicity & disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed.
- Common variants in the Na(+)-coupled bicarbonate transporter genes and salt sensitivity of blood pressure: the GenSalt study.Journal of human hypertension · 2016Trial
- The role of NaPflugers Archiv : European journal of physiology · 2024Review
- NBCe2 (Frontiers in physiology · 2020Article
- Novel DNA methylation sites associated with cigarette smoking among African Americans.Epigenetics · 2019Article
- Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships.Biological research for nursing · 2018Article
- Perceived Racial Discrimination and DNA Methylation Among African American Women in the InterGEN Study.Biological research for nursing · 2018Article
- The combined effects of genetic risk and perceived discrimination on blood pressure among African Americans in the Jackson Heart Study.Medicine · 2017Article
- The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) Study: Design and Methods for Complex DNA Analysis.Biological research for nursing · 2016Article
- The Renal Sodium Bicarbonate Cotransporter NBCe2: Is It a Major Contributor to Sodium and pH Homeostasis?Current hypertension reports · 2016Review
- Genetic Loci and Novel Discrimination Measures Associated with Blood Pressure Variation in African Americans Living in Tallahassee.PloS one · 2016Article
- A perspective for sequencing familial hypercholesterolaemia in African Americans.NPJ genomic medicine · 2016Article
- The National Institute on Aging Health Disparities Research Framework.Ethnicity & disease · 2015Review
- Disturbed acid-base transport: an emerging cause of hypertension.Frontiers in physiology · 2013Review
- The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.Physiological reviews · 2013Review
- Cardiovascular genomics.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2013Review
- Association Between Stress and Coping with DNA Methylation of Blood Pressure-Related Genes Among African American Women.Chronic stress (Thousand Oaks, Calif.)Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo determine the relationship between genetic polymorphisms and environmental factors (skin color) on blood pressure among African American women.
methodA descriptive study, consisting of 137 African American women from a Midwestern, metropolitan area was conducted. Blood pressure was measured using a digital blood pressure monitor. Self-reporting methods were utilized to obtain information on skin color. Buccal swab saliva samples were obtained for genotyping.
resultsOf the four single nucleotide polymorphisms (SNPs) on the sodium bicarbonate co-transporter gene (SLC4A5) examined in this study, only one SNP (rs10177833) and skin color interaction was found to be associated with systolic blood pressure. The additive effect of rs10177833 on systolic blood pressure is statistically different between women with dark skin color and women with medium skin color (P = .0153). No SNP and skin color interaction was found to be associated with blood pressure readings in other SNPs tested (rs8179526, rs6726450 and rs6731545). DISCUSSION: These findings of genetic and skin color relatedness to blood pressure is important when considering appropriate diagnostic and treatment plans for African American women with hypertension. African American women with darker skin color may require further assessment for risk factors such as discrimination related stress when being seen by health professionals for hypertension.
Indexed as
Identifiers
22764636PMC3391738What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.