ArticleThe American journal of tropical medicine and hygiene2012
Development of new, broadly reactive, rapid IgG and IgM lateral flow assays for diagnosis of scrub typhus.
Article in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Scrub typhus point-of-care testing: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2018Pooled it
- Neglected rickettsial diseases in Southeast Asia: Twenty-five years of progress in surveillance, diagnostics, and clinical research.PLoS neglected tropical diseases · 2026Review
- Diagnosis of scrub typhus: recent advancements and challenges.3 Biotech · 2020Review
- An Observational Study of Sepsis in Takeo Province Cambodia: An in-depth examination of pathogens causing severe infections.PLoS neglected tropical diseases · 2020Observational
- Scrub typhus with multi-organ dysfunction syndrome and immune thrombocytopenia: a case report and review of the literature.Journal of medical case reports · 2019Review
- Assessment of a Sensitive qPCR Assay Targeting a Multiple-Copy Gene to DetectTropical medicine and infectious disease · 2019Article
- Origins, Importance and Genetic Stability of the Prototype Strains Gilliam, Karp and Kato ofTropical medicine and infectious disease · 2019Review
- An ELISA assay using a combination of recombinant proteins from multiple strains of Orientia tsutsugamushi offers an accurate diagnosis for scrub typhus.BMC infectious diseases · 2017Article
- State of the art of diagnosis of rickettsial diseases: the use of blood specimens for diagnosis of scrub typhus, spotted fever group rickettsiosis, and murine typhus.Current opinion in infectious diseases · 2016Review
- Diagnostic evaluation of rapid tests for scrub typhus in the Indian population is needed.Infectious diseases of poverty · 2016Article
- Diagnostic Accuracy Assessment of Immunochromatographic Tests for the Rapid Detection of Antibodies Against Orientia tsutsugamushi Using Paired Acute and Convalescent Specimens.The American journal of tropical medicine and hygiene · 2015Article
- Dot-ELISA Rapid Test Using Recombinant 56-kDa Protein Antigens for Serodiagnosis of Scrub Typhus.The American journal of tropical medicine and hygiene · 2015Article
- A rapid lateral flow immunoassay for the detection of tyrosine phosphatase-like protein IA-2 autoantibodies in human serum.PloS one · 2014Article
- Scrub typhus associated hepatic dysfunction and abdominal CT findings.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the diagnostic accuracy of two broadly reactive rapid immunochromatographic tests (ICTs) for detection of IgM and IgG against Orientia tsutsugamushi by using archived acute-phase serum samples from 102 patients with laboratory-confirmed scrub typhus, and from 62 archived serum samples from patients with other causes of fever as a negative control. These ICTs were constructed by using a mixture of recombinant proteins: 1) C1, a chimeric protein containing epitopes of the 56-kD antigen from Karp and TA763 strains; 2) Ktr56; and 3) Gmr56. Sensitivities of the ICTs for detection of IgM and IgG were 90.2% (95% confidence interval [CI] = 84.4-96.0%) and 86.3% (95% CI = 80.9-93.8%), respectively. Specificities were 85.5% (95% CI = 73.9-92.2%) and 96.8% (95% CI = 90.3-100%), respectively. Both assays were more sensitive and specific than the standard immune immunofluorescence assay for the early diagnosis of scrub typhus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.