SynthesisThe American journal of tropical medicine and hygiene2012
Reduction of malaria prevalence by indoor residual spraying: a meta-regression analysis.
Synthesis in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Effect of Indoor Residual Spraying on Malaria in Pregnancy and Pregnancy Outcomes: A Systematic Review.The American journal of tropical medicine and hygiene · 2025Pooled it
- Reducing Malaria Transmission through Reactive Indoor Residual Spraying: A Systematic Review.The American journal of tropical medicine and hygiene · 2024Pooled it
- Effectiveness of indoor residual spraying on malaria control: a systematic review and meta-analysis.Infectious diseases of poverty · 2022Pooled it
- Comparative effectiveness of malaria prevention measures: a systematic review and network meta-analysis.Parasites & vectors · 2018Pooled it
- A Meta-Regression Analysis of the Effectiveness of Mosquito Nets for Malaria Control: The Value of Long-Lasting Insecticide Nets.International journal of environmental research and public health · 2018Pooled it
- The associations between malaria, interventions, and the environment: a systematic review and meta-analysis.Malaria journal · 2018Pooled it
- Trial
- Trends in the selection of insecticide resistance in Anopheles gambiae s.l. mosquitoes in northwest Tanzania during a community randomized trial of longlasting insecticidal nets and indoor residual spraying.Medical and veterinary entomology · 2015Trial
- Impact of Late-Rainy Season Indoor Residual Spraying on Holoendemic Malaria Transmission: A Cohort Study in Northern Zambia.The Journal of infectious diseases · 2025Article
- Indoor residual spraying uptake and its effect on malaria morbidity in Ngoma district, Eastern province of Rwanda, 2018-2021.Malaria journal · 2024Article
- Revolutionizing Malaria Vector Control: The Importance of Accurate Species Identification through Enhanced Molecular Capacity.Microorganisms · 2023Review
- Differential Influence of Environmental Factors on Malaria Due to Vector Control Interventions in Uganda.International journal of environmental research and public health · 2023Article
- Seasonal variation in abundance and blood meal sources of primary and secondary malaria vectors within Kilombero Valley, Southern Tanzania.Parasites & vectors · 2022Article
- Indoor residual spraying with a non-pyrethroid insecticide reduces the reservoir ofPLOS global public health · 2022Article
- Performance of IRS on malaria prevalence and incidence using pirimiphos-methyl in the context of pyrethroid resistance in Koulikoro region, Mali.Malaria journal · 2020Article
- Article
- An exploratory study of the acceptability of indoor residual spraying for malaria control in upper western Ghana.BMC public health · 2020Article
- Investigating the upsurge of malaria prevalence in Zambia between 2010 and 2015: a decomposition of determinants.Malaria journal · 2019Article
- Effects and factors associated with indoor residual spraying with Actellic 300 CS on malaria morbidity in Lira District, Northern Uganda.Malaria journal · 2019Article
- Reshaping the vector control strategy for malaria elimination in Ethiopia in the context of current evidence and new tools: opportunities and challenges.Malaria journal · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Indoor residual spraying (IRS) has become an increasingly popular method of insecticide use for malaria control, and many recent studies have reported on its effectiveness in reducing malaria burden in a single community or region. There is a need for systematic review and integration of the published literature on IRS and the contextual determining factors of its success in controlling malaria. This study reports the findings of a meta-regression analysis based on 13 published studies, which were chosen from more than 400 articles through a systematic search and selection process. The summary relative risk for reducing malaria prevalence was 0.38 (95% confidence interval = 0.31-0.46), which indicated a risk reduction of 62%. However, an excessive degree of heterogeneity was found between the studies. The meta-regression analysis indicates that IRS is more effective with high initial prevalence, multiple rounds of spraying, use of DDT, and in regions with a combination of Plasmodium falciparum and P. vivax malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.