Trial reportThe American journal of tropical medicine and hygiene2012
Assessment of interferon-γ levels and leishmanin skin test results in persons recovered for leishmaniasis.
Trial report in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Lymphocyte-mediated immune responses to Leishmania infection.Nature reviews. Immunology · 2026Review
- An observational study to test the potency of GLP-grade phenol-free lyophilised leishmanin antigen formulation.EBioMedicine · 2026Article
- Memory T cells: promising biomarkers for evaluating protection and vaccine efficacy against leishmaniasis.Frontiers in immunology · 2024Review
- A Historic Review of the Role of CD4+ T-Cell Subsets in Development of the Immune Responses against Cutaneous and Visceral LeishmaniasesIranian biomedical journal · 2022Review
- A review of the leishmanin skin test: A neglected test for a neglected disease.PLoS neglected tropical diseases · 2021Review
- Potential biomarkers of immune protection in human leishmaniasis.Medical microbiology and immunology · 2021Review
- Whole Blood Stimulation Assay as a Treatment Outcome Monitoring Tool for VL Patients in Ethiopia: A Pilot Evaluation.Journal of immunology research · 2020Article
- Cellular Markers of Active Disease and Cure in Different Forms ofFrontiers in cellular and infection microbiology · 2018Article
- Cutaneous leishmaniasis: recent developments in diagnosis and management.American journal of clinical dermatology · 2015Review
- Visceral leishmaniasis and HIV coinfection in the Mediterranean region.PLoS neglected tropical diseases · 2014Review
- Whole blood assay and visceral leishmaniasis: Challenges and promises.Immunobiology · 2014Review
- Epidemiology of visceral leishmaniasis in Georgia.PLoS neglected tropical diseases · 2014Article
- Article
- Comparative Analysis of Microscopy, Leishmanin Skin Test (LST), and Direct Agglutination Test (DAT) for the Diagnosis of Human Cutaneous Leishmaniasis.Iranian journal of parasitologyArticle
- Predominance of Leishmania major and rare occurrence of Leishmania tropica with haplotype variability at the center of Iran.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients who recover from leishmaniasis usually show development of strong immunity and induction of interferon-γ (IFN-γ) and delayed type hypersensitivity. In a randomized trial, we analyzed the IFN-γ response by using a Quantiferon-Leishmania assay against three Leishmania peptide antigens and compared it with results of the leishmanin skin test (LST) in persons residing in areas in Iran to which zoonotic cutaneous leishmaniasis (ZCL, 181 persons), anthroponotic cutaneous leishmaniasis (ACL, 104 persons), and zoonotic visceral leishmaniasis (ZVL, 67 persons) are endemic. The percentage of persons with an IFN-γ-positive response (> 0.2 IU/mL) to three antigens and the mean concentration of IFN-γ induced by the antigens were higher for persons from areas endemic for ZVL than for persons from areas endemic for ZCL and ACL. The percentage of persons with LST-positive results (≥ 5 mm indurations) was 99%, 94%, and 70% for areas with ZCL, ACL, and ZVL, respectively. Our data indicate that the LST is significantly more sensitive than IFN-γ levels in persons who have been cured of cutaneous leishmaniasis than in persons who have been cured of ZVL.
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