Evidence map›Paper›PMID 22764257›Full record

ArticleNeurology2012

Seizure risk with AVM treatment or conservative management: prospective, population-based study.

Colin B Josephson, Jo J Bhattacharya, Carl E Counsell, Vakis Papanastassiou, Vaughn Ritchie, Richard Roberts, Robin Sellar, Charles P Warlow, Rustam Al-Shahi Salman, Scottish Audit of Intracranial Vascular Malformations (SAIVMs) steering committee and collaborators

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Epilepsy Secondary to a Giant AVM: A Case Report.Case reports in vascular medicine · 2025
    Article
  6. Article
  7. Peripheral macrophages in the development and progression of structural cerebrovascular pathologies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Review
  13. Arteriovenous Malformations-Associated Epilepsy in Pediatrics.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Diagnosis and treatment of arteriovenous malformations.Current neurology and neuroscience reports · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Colin B JosephsonDivision of Clinical Neurosciences, Centre for Clinical Brain Sciences, University of Edinburgh, Western General Hospital, Edinburgh, UK.
Jo J Bhattacharya
Carl E Counsell
Vakis Papanastassiou
Vaughn Ritchie
Richard Roberts
Robin Sellar
Charles P Warlow
Rustam Al-Shahi Salman
Scottish Audit of Intracranial Vascular Malformations (SAIVMs) steering committee and collaborators
Institute of Neurological Sciences · ITUniversity of Edinburgh · GBUniversity of Aberdeen · GBNational Health Service Scotland · GBSouthern General Hospital · GBWestern General Hospital · GB

Funding

Medical Research Council G1002605Medical Research Council G108/613
6 · The paper itself

Abstract

objectivesTo compare the risk of epileptic seizures in adults during conservative management or following invasive treatment for a brain arteriovenous malformation (AVM).

methodsWe used annual general practitioner follow-up, patient questionnaires, and medical records surveillance to quantify the 5-year risk of seizures and the chances of achieving 2-year seizure freedom for adults undergoing AVM treatment compared to adults managed conservatively in a prospective, population-based observational study of adults in Scotland, newly diagnosed with an AVM in 1999-2003.

resultsWe identified 229 adults with a new diagnosis of an AVM, of whom two-thirds received AVM treatment (154/229; 67%) during 1,862 person-years of follow-up (median completeness of follow-up 97%). There was no significant difference in the proportions with a first or recurrent seizure over 5 years following AVM treatment, compared to the first 5 years following clinical presentation in conservatively managed adults, in analyses stratified by mode of presentation (intracerebral hemorrhage, 35% vs 26%, p = 0.5; seizure, 67% vs 72%, p = 0.6; incidental, 21% vs 10%, p = 0.4). For patients with epilepsy, the chances of achieving 2-year seizure freedom during 5-year follow-up were similar following AVM treatment (n = 39; 52%, 95% confidence interval [CI] 36% to 68%) or conservative management (n = 21; 57%, 95% CI 35% to 79%; p = 0.7).

conclusionsIn this observational study, there was no difference in the 5-year risk of seizures with AVM treatment or conservative management, irrespective of whether the AVM had presented with hemorrhage or epileptic seizures.

Indexed as

AdultArteriovenous FistulaEmbolization, TherapeuticFemaleHumansIntracranial Arteriovenous MalformationsMaleMiddle AgedNeurosurgical ProceduresRadiosurgeryRisk FactorsSeizures

Identifiers

PMID22764257
PMCPMC3413766
OpenAlexW2114512170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.