ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Axial organization of a brain region that sequences a learned pattern of behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Article
- Morphological characterization of HVC projection neurons in the zebra finch (Taeniopygia guttata).The Journal of comparative neurology · 2018Article
- Stable Sequential Activity Underlying the Maintenance of a Precisely Executed Skilled Behavior.Neuron · 2018Article
- Cortical inter-hemispheric circuits for multimodal vocal learning in songbirds.The Journal of comparative neurology · 2017Article
- Dissociable Effects on Birdsong of Androgen Signaling in Cortex-Like Brain Regions of Canaries.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A distributed neural network model for the distinct roles of medial and lateral HVC in zebra finch song production.Journal of neurophysiology · 2017Article
- Model of the songbird nucleus HVC as a network of central pattern generators.Journal of neurophysiology · 2016Article
- Neural Sequence Generation Using Spatiotemporal Patterns of Inhibition.PLoS computational biology · 2015Article
- Mesoscopic patterns of neural activity support songbird cortical sequences.PLoS biology · 2015Article
- Imaging auditory representations of song and syllables in populations of sensorimotor neurons essential to vocal communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Interplay of inhibition and excitation shapes a premotor neural sequence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Independent premotor encoding of the sequence and structure of birdsong in avian cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Rhythmic cortical neurons increase their oscillations and sculpt basal ganglia signaling during motor learning.Developmental neurobiology · 2013Article
- Directed functional connectivity matures with motor learning in a cortical pattern generator.Journal of neurophysiology · 2013Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Neural activity within HVC (proper name), a premotor nucleus of the songbird telencephalon analogous to premotor cortical regions in mammals, controls the temporal structure of learned song in male zebra finches (Taeniopygia guttata). HVC is composed of a superficially isomorphic neuronal mosaic, implying that song is encoded in a distributed network within HVC. Here, we combined HVC microlesions (10% focal ablation) with singing-driven immediate-early gene (IEG) labeling to explore the network architecture of HVC during singing. Microlesions produce a transient disruption of HVC activity that results in a temporary (≈ 1 week) loss of vocal patterning. Results showed an asymmetrical reduction in the density of IEG-labeled cells 3-5 d after microlesions: swaths of unlabeled cells extended rostrally and/or caudally depending on the position of the HVC microlesion. Labeling returned once birds recovered their songs. Axial swaths of unlabeled cells occurred whether microlesions were located at rostral or caudal poles of HVC, indicating that the localized reduction in IEG labeling could not be attributable solely to transection of afferents that enter HVC rostrally. The asymmetrical pattern of reduced IEG labeling could be explained if synaptic connectivity within HVC is organized preferentially within the rostrocaudal axis. In vivo retrograde tracer injections and in vitro stimulation and recording experiments in horizontal slices of HVC confirmed a rostrocaudal organization of HVC neural connectivity. Our findings suggest that HVC contains an axially organized network architecture that may encode the temporal structure of song.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.