ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Generating synchrony from the asynchronous: compensation for cochlear traveling wave delays by the dendrites of individual brainstem neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 65 citations in OpenAlex.
- Synaptic input variation enhances rate coding at the expense of temporal precision in cochlear nucleus neurons.PLoS biology · 2026Article
- An anatomical and physiological basis for flexible coincidence detection in the auditory system.eLife · 2025Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.Nature communications · 2025Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.bioRxiv : the preprint server for biology · 2024Article
- Asymmetry in the Perception of Electrical Chirps Presented to Cochlear Implant Listeners.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Characterizing the relationship between modulation sensitivity and pitch resolution in cochlear implant users.Hearing research · 2024Article
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- A chemo-mechanical cochleostomy preserves hearing for the in vivo functional imaging of cochlear cells.Nature protocols · 2023Review
- Imaging Voltage Globally and in Isofrequency Lamina in Slices of Mouse Ventral Cochlear Nucleus.eNeuro · 2023Article
- Mammalian octopus cells are direction selective to frequency sweeps by excitatory synaptic sequence detection.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Interplay between traveling wave propagation and amplification at the apex of the mouse cochlea.Biophysical journal · 2022Article
- In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Computational Modeling of Synchrony in the Auditory Nerve in Response to Acoustic and Electric Stimulation.Frontiers in computational neuroscience · 2022Article
- Periodicity Pitch Perception Part III: Sensibility and Pachinko Volatility.Frontiers in neuroscience · 2022Article
- A phenomenological spiking model for octopus cells in the posterior-ventral cochlear nucleus.Biological cybernetics · 2021Article
- Information Processing by Onset Neurons in the Cat Auditory Brainstem.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Periodicity Pitch Perception.Frontiers in neuroscience · 2020Article
- Active membrane conductances and morphology of a collision detection neuron broaden its impedance profile and improve discrimination of input synchrony.Journal of neurophysiology · 2019Article
- Article
- Effects of cochlear synaptopathy on middle-ear muscle reflexes in unanesthetized mice.Hearing research · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Broadband transient sounds, such as clicks and consonants, activate a traveling wave in the cochlea. This wave evokes firing in auditory nerve fibers that are tuned to high frequencies several milliseconds earlier than in fibers tuned to low frequencies. Despite this substantial traveling wave delay, octopus cells in the brainstem receive broadband input and respond to clicks with submillisecond temporal precision. The dendrites of octopus cells lie perpendicular to the tonotopically organized array of auditory nerve fibers, placing the earliest arriving inputs most distally and the latest arriving closest to the soma. Here, we test the hypothesis that the topographic arrangement of synaptic inputs on dendrites of octopus cells allows octopus cells to compensate the traveling wave delay. We show that in mice the full cochlear traveling wave delay is 1.6 ms. Because the dendrites of each octopus cell spread across approximately one-third of the tonotopic axis, a click evokes a soma-directed sweep of synaptic input lasting 0.5 ms in individual octopus cells. Morphologically and biophysically realistic, computational models of octopus cells show that soma-directed sweeps with durations matching in vivo measurements result in the largest and sharpest somatic EPSPs. A low input resistance and activation of a low-voltage-activated potassium conductance that are characteristic of octopus cells are important determinants of sweep sensitivity. We conclude that octopus cells have dendritic morphologies and biophysics tailored to accomplish the precise encoding of broadband transient sounds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.