ArticleProceedings. Biological sciences2012
Evolutionary dynamics of genome segmentation in multipartite viruses.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 67 citations in OpenAlex.
- Article
- Living Together Apart: Quantitative Perspectives on the Costs and Benefits of a Multipartite Genome Organization in Viruses.Viruses · 2025Article
- Relative frequency dynamics and loading of beet necrotic yellow vein virus genomic RNAs during the acquisition by its vectorJournal of virology · 2025Article
- Genome segment ratios change during whitefly transmission of two bipartite cassava mosaic begomoviruses.Scientific reports · 2023Article
- Article
- Cheating leads to the evolution of multipartite viruses.PLoS biology · 2023Article
- Structure-guided mutagenesis of the capsid protein indicates that a nanovirus requires assembled viral particles for systemic infection.PLoS pathogens · 2023Article
- Nonconcomitant host-to-host transmission of multipartite virus genome segments may lead to complete genome reconstitution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Towards an integrative view of virus phenotypes.Nature reviews. Microbiology · 2022Review
- Gene copy number variations at the within-host population level modulate gene expression in a multipartite virus.Virus evolution · 2022Article
- Unresolved advantages of multipartitism in spatially structured environments.Virus evolution · 2021Article
- RNAi technology for management of banana bunchy top disease.Food and energy security · 2020Review
- Route of a Multipartite Nanovirus across the Body of Its Aphid Vector.Journal of virology · 2020Article
- A tripartite ssDNA mycovirus from a plant pathogenic fungus is infectious as cloned DNA and purified virions.Science advances · 2020Article
- Nanovirus Disease Complexes: An Emerging Threat in the Modern Era.Frontiers in plant science · 2020Review
- Modeling multipartite virus evolution: the genome formula facilitates rapid adaptation to heterogeneous environmentsVirus evolution · 2020Article
- Article
- Endemicity and prevalence of multipartite viruses under heterogeneous between-host transmission.PLoS computational biology · 2019Article
- Collective properties of viral infectivity.Current opinion in virology · 2018Review
- Small Bottleneck Size in a Highly Multipartite Virus during a Complete Infection Cycle.Journal of virology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multipartite viruses are formed by a variable number of genomic fragments packed in independent viral capsids. This fact poses stringent conditions on their transmission mode, demanding, in particular, a high multiplicity of infection (MOI) for successful propagation. The actual advantages of the multipartite viral strategy are as yet unclear. The origin of multipartite viruses represents an evolutionary puzzle. While classical theories suggested that a faster replication rate or higher replication fidelity would favour shorter segments, recent experimental results seem to point to an increased stability of virions with incomplete genomes as a factor able to compensate for the disadvantage of mandatory complementation. Using as main parameters differential stability as a function of genome length and MOI, we calculate the conditions under which a set of complementary segments of a viral genome would outcompete the non-segmented variant. Further, we examine the likeliness that multipartite viral forms could be the evolutionary outcome of the competition among the defective genomes of different lengths that spontaneously arise under replication of a complete, wild-type genome. We conclude that only multipartite viruses with a small number of segments could be produced in our scenario, and discuss alternative hypotheses for the origin of multipartite viruses with more than four segments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.