ArticleDevelopment (Cambridge, England)2012
Identification of a novel developmental mechanism in the generation of mesothelia.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- The pericardium forms as a distinct structure during heart formation.Nature communications · 2025Article
- Dynamic WT1 expression during gastrulation specifies peritoneal smooth muscle fate independently of mesothelial fate.Development (Cambridge, England) · 2025Article
- Stage-specific nutritional management and developmental programming to optimize meat production.Journal of animal science and biotechnology · 2023Review
- Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma.Nature communications · 2022Article
- Suspension culture promotes serosal mesothelial development in human intestinal organoids.Cell reports · 2022Article
- Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice.Scientific reports · 2021Article
- Post-Surgical Peritoneal Scarring and Key Molecular Mechanisms.Biomolecules · 2021Review
- The lateral plate mesoderm.Development (Cambridge, England) · 2020Review
- Mesothelium and Malignant Mesothelioma.Journal of developmental biology · 2019Review
- Assembling the adipose organ: adipocyte lineage segregation and adipogenesisDevelopment (Cambridge, England) · 2019Review
- A Subset of Malignant Mesothelioma Tumors Retain Osteogenic Potential.Scientific reports · 2016Article
- The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration.Gut and liver · 2016Review
- Role of TGF-β signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Characterisation of Cultured Mesothelial Cells Derived from the Murine Adult Omentum.PloS one · 2016Article
- Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis.The American journal of pathology · 2015Article
- Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis.Developmental biology · 2014Article
- Article
- Expression and diagnostic values of calretinin and CK5/6 in cholangiocarcinoma.Experimental hematology & oncology · 2014Article
- Comprehensive timeline of mesodermal development in the quail small intestine.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mesothelium is the surface layer of all coelomic organs and is crucial for the generation of their vasculature. Still, our understanding of the genesis of this essential cell type is restricted to the heart where a localized exogenous population of cells, the proepicardium, migrates to and envelops the myocardium supplying mesothelial, vascular and stromal cell lineages. Currently it is not known whether this pattern of development is specific to the heart or applies broadly to other coelomic organs. Using two independent long-term lineage-tracing studies, we demonstrate that mesothelial progenitors of the intestine are intrinsic to the gut tube anlage. Furthermore, a novel chick-quail chimera model of gut morphogenesis reveals these mesothelial progenitors are broadly distributed throughout the gut primordium and are not derived from a localized and exogenous proepicardium-like source of cells. These data demonstrate an intrinsic origin of mesothelial cells to a coelomic organ and provide a novel mechanism for the generation of mesothelial cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.