Evidence map›Paper›PMID 22763734›Full record

SynthesisMolecular biology reports2012

Association of the IL-10 polymorphisms and periodontitis: a meta-analysis.

C M Albuquerque, A J Cortinhas, F J Morinha, J C Leitão, C A Viegas, E M Bastos

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 14 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 14 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  18. Genomic Medicine in Canine Periodontal Disease: A Systematic Review.Animals : an open access journal from MDPI · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

C M AlbuquerqueCentre of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, Institute for Biotechnology and Bioengineering (CGB-UTAD/IBB), Quinta dos Prados, P.O. Box 1013, 5001-801 Vila Real, Portugal. cmralb@hotmail.com
A J Cortinhas
F J Morinha
J C Leitão
C A Viegas
E M Bastos
University of Trás-os-Montes and Alto Douro · PTInstitute for Biotechnology and Bioengineering · PTUniversity of Minho · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

No clear consensus has been reached regarding the association of IL-10 polymorphisms and periodontitis. Therefore, we performed a meta-analysis of case-control studies and a systemic review in an effort to systematically summarize the existing knowledge. Studies were identified by searching PubMed database until December 2011. IL-10 -1082 (-1087) A>G, -819 (-824) C>T and -592 (-597) C>A polymorphisms were included in the present meta-analysis. We calculated the specific odds ratios along with their 95 % confidence intervals to compare the distribution of alleles and genotypes between cases and controls. An additive "per-allele" model (major allele vs. minor allele) was performed, and dominant and recessive models were also considered. The random-effects model was applied for the analysis. Cumulative analysis was also performed. Heterogeneity and publication bias were assessed. Nine case-control studies involving 841 periodontitis cases (644 chronic periodontitis and 197 aggressive periodontitis cases) and 748 controls were included. We found statistically significant association of IL-10 -819 (-824) C>T and IL-10 -592 (-597) C>A polymorphisms in Caucasians. The IL-10 -819 (-824) T and -592 (-597) A alleles may confer a relative increase in the risk for chronic periodontitis in Caucasians. Future studies may be important to reinforce these findings.

Indexed as

Polymorphism, Single NucleotideCase-Control StudiesGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansInterleukin-10Linkage DisequilibriumPeriodontitisPromoter Regions, GeneticRiskIL10 protein, humanInterleukin-10

Identifiers

PMID22763734
OpenAlexW2049070802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.