ArticlePsychopharmacology2012
Discrimination of ethanol-nicotine drug mixtures in mice: dual interactive mechanisms of overshadowing and potentiation.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The incentive amplifying effects of nicotine: Roles in alcohol seeking and consumption.Advances in pharmacology (San Diego, Calif.) · 2022Review
- Role of mPFC and nucleus accumbens circuitry in modulation of a nicotine plus alcohol compound drug state.Addiction biology · 2020Article
- Ethanol→Nicotine & Nicotine→Ethanol drug-sequence discriminations: Conditional stimulus control with two interoceptive drug elements in rats.Alcohol (Fayetteville, N.Y.) · 2019Article
- Interactions between nicotine and drugs of abuse: a review of preclinical findings.The American journal of drug and alcohol abuse · 2017Review
- The nicotine + alcohol interoceptive drug state: contribution of the components and effects of varenicline in rats.Psychopharmacology · 2016Article
- Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Nicotine and ethanol co-use in Long-Evans rats: Stimulatory effects of perinatal exposure to a fat-rich diet.Alcohol (Fayetteville, N.Y.) · 2015Article
- Effects of nicotine on ethanol-induced locomotor sensitization: A model of neuroadaptation.Behavioural brain research · 2015Article
- Contribution of NMDA glutamate and nicotinic acetylcholine receptor mechanisms in the discrimination of ethanol-nicotine mixtures.Behavioural pharmacology · 2013Article
- Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol.Current topics in behavioral neurosciencesReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
rationaleOne possible basis for the proclivity of ethanol and nicotine co-abuse is an interaction between the discriminative stimulus (S(D)) effects of each drug.
objectivesThe current work sought to assess the discriminative control of ethanol and nicotine cues in mice trained with drug mixtures and to determine whether interactive mechanisms of overshadowing and potentiation occur.
methodsMale C57BL/6J mice were trained to discriminate ethanol (1.5 g/kg) alone or ethanol plus nicotine (0.4, 0.8, or 1.2 mg/kg base) in experiment 1 and nicotine (0.8 mg/kg) alone or nicotine plus ethanol (0.5, 1.0, or 2.0 g/kg) in experiment 2. Stimulus generalizations of the training mixtures to ethanol, nicotine, and the drug combination were assessed.
resultsEthanol (1.5 g/kg) retained discriminative control despite the inclusion of a progressively larger nicotine dose within the training mixtures in experiment 1. Although the nicotine S(D) was overshadowed by ethanol training doses > 0.5 g/kg in experiment 2, nicotine did potentiate the effects of low-dose ethanol.
conclusionsThese findings are suggestive of dual mechanisms whereby ethanol (>0.5 g/kg) overshadows the S(D) effects of nicotine, and at lower doses (<1 g/kg) the salience of ethanol's S(D) effects is potentiated by nicotine. These mechanisms may contribute to the escalation of concurrent drinking and smoking in a binge-like fashion.
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