ArticleThe protein journal2012
Highly upregulated expression of CD36 and MSR1 in circulating monocytes of patients with acute coronary syndromes.
Article in The protein journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 54 citations in OpenAlex.
- Integrative multi-omics identifiesFrontiers in immunology · 2026Article
- Iron-dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP-1 monocytes.FEBS open bio · 2025Article
- Monocyte CD36 Expression Predicts Disease Activity in Patients With Crohn's Disease.Gastroenterology research and practice · 2024Article
- The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children: The ActiveBrains project.Journal of sport and health science · 2023Article
- Genetic variants, gene expression, and soluble CD36 analysis in acute coronary syndrome: Differential protein concentration between ST-segment elevation myocardial infarction and unstable angina.Journal of clinical laboratory analysis · 2022Article
- Expression of Macrophage Scavenger Receptor (MSR1) in Peripheral Blood Cells from Patients with Different Respiratory Diseases: Beyond Monocytes.Journal of clinical medicine · 2022Article
- Identification of candidate biomarkers and therapeutic agents for heart failure by bioinformatics analysis.BMC cardiovascular disorders · 2021Article
- CD36 in Atherosclerosis: Pathophysiological Mechanisms and Therapeutic Implications.Current atherosclerosis reports · 2020Review
- Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.Journal of lipid research · 2020Article
- Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1-dependent mechanisms of cardiac repair.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Mechanisms of foam cell formation in atherosclerosis.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Association between rs1761667 polymorphism of CD36 gene and risk of coronary atherosclerosis in Egyptian population.Cardiovascular diagnosis and therapy · 2016Article
- Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity.Journal of diabetes research · 2016Article
- Macrophage-mediated cholesterol handling in atherosclerosis.Journal of cellular and molecular medicine · 2016Review
- Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis.International journal of cardiology · 2015Article
- Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans.JACC. Cardiovascular imaging · 2015Article
- A vascular biology network model focused on inflammatory processes to investigate atherogenesis and plaque instability.Journal of translational medicine · 2014Article
- TNFa alter cholesterol metabolism in human macrophages via PKC-θ-dependent pathway.BMC biochemistry · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute Coronary Syndromes (ACS) are a group of disorders caused by the significant reduction of circulation in coronary arteries. The most common reason of the dysfunction is a blood clot formed in place of plaque rupture. The role of scavenger receptors in development and progression of atherosclerosis has been confirmed in many animal experiments, however the knowledge about contribution of the receptors in the development of ACS symptoms in humans still remains insufficient. The aim of this work was to define the expression of two scavenger receptors: CD36 and MSR1 in monocytes of patients with ACS after the onset of symptoms and after the 6 months of treatment. The analysis of CD36 and MSR1 expression was carried out with the use of real-time PCR and flow cytometry. Analyses of lipid and glucose concentration in blood and the level of inflammatory markers in plasma were performed additionally for all ACS patients. All data obtained during the research were analyzed using statistical tests, such as Mann Whitney test, Wilcoxon test, or correlation. In all patients with symptoms of ACS the amount of CD36 and MSR1 mRNA in circulating monocytes, as well as the density of both receptors on the cells surface was significantly higher. Re-analysis of subjects after 6 months of treatment, showed a significant decrease in the CD36 and MSR1 expression in all patients who received atorvastatin. The results of presented studies demonstrate that both investigated receptors are involved in the development and/or progression of ACS.
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Registered trials
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