ArticleNature2012
Live imaging of stem cell and progeny behaviour in physiological hair-follicle regeneration.
Article in Nature, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
229 citing papers in PubMed, 382 citations in OpenAlex.
- Studying Hair Growth in Mice: Synchronization of Hair Follicle Growth by Depilation.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Sharp cell type boundaries emerge from coordinated morphogen signaling.Genes & development · 2026Article
- Article
- Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies.Cell communication and signaling : CCS · 2026Review
- Dual lineages of Langerhans cells cooperate to restore the immune barrier after skin injury.bioRxiv : the preprint server for biology · 2026Article
- Molecular signatures and signaling interactions of the hair follicle stem cell niche.The Journal of investigative dermatology · 2026Article
- Overview of Short Peptides for Hair Loss.Biomedicines · 2026Review
- Preferential crosstalk between perifollicular capillary vessels and dermal papilla cells during hair cycling homeostasis.Scientific reports · 2026Article
- Intrinsic mechanisms and microenvironmental cues fine-tune plasticity of esophageal progenitors.Nature communications · 2026Article
- From a stem-cell-centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization.Frontiers in cell and developmental biology · 2026Review
- A Comprehensive Review of GWASs of Human Hair Traits.The Journal of investigative dermatology · 2025Review
- The human umbilical cord-mesenchymal stem cell secretome regulates hair growth and cycle transition by promoting methylthioadenosine synthesis via the PI3K/AKT/mTOR pathway.Stem cell research & therapy · 2025Article
- Mapping cell dynamics in human ex vivo hair follicles suggests pulling mechanism of hair growth.Nature communications · 2025Article
- Emerging biomedical engineering strategies for hair follicle regeneration.Bioactive materials · 2025Review
- Article
- An intermediate activation state primes Langerhans cell migration from the epidermis.bioRxiv : the preprint server for biology · 2025Article
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs.eLife · 2025Article
- Enhancing the purity and intrinsic properties of ovine dermal papilla cells through flow cytometry sorting and cellular interactions.Animal bioscience · 2025Article
- Interaction of Wnt and SHH gradients synchronizes cell cycle exit and differentiation.bioRxiv : the preprint server for biology · 2025Article
169 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Tissue development and regeneration depend on cell-cell interactions and signals that target stem cells and their immediate progeny. However, the cellular behaviours that lead to a properly regenerated tissue are not well understood. Using a new, non-invasive, intravital two-photon imaging approach we study physiological hair-follicle regeneration over time in live mice. By these means we have monitored the behaviour of epithelial stem cells and their progeny during physiological hair regeneration and addressed how the mesenchyme influences their behaviour. Consistent with earlier studies, stem cells are quiescent during the initial stages of hair regeneration, whereas the progeny are more actively dividing. Moreover, stem cell progeny divisions are spatially organized within follicles. In addition to cell divisions, coordinated cell movements of the progeny allow the rapid expansion of the hair follicle. Finally, we show the requirement of the mesenchyme for hair regeneration through targeted cell ablation and long-term tracking of live hair follicles. Thus, we have established an in vivo approach that has led to the direct observation of cellular mechanisms of growth regulation within the hair follicle and that has enabled us to precisely investigate functional requirements of hair-follicle components during the process of physiological regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.