ArticleBiological psychiatry2012
Attention-related Pearce-Kaye-Hall signals in basolateral amygdala require the midbrain dopaminergic system.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neurons of Macaque Frontal Eye Field Signal Reward-Related Surprise.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neural Representation of Valenced and Generic Probability and Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories.Nature neuroscience · 2024Article
- Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Review
- Neural signals implicated in the processing of appetitive and aversive events in social and non-social contexts.Frontiers in systems neuroscience · 2022Review
- Uncertainty and predictiveness modulate attention in human predictive learning.Journal of experimental psychology. General · 2021Article
- Review
- Prediction errors and valence: From single units to multidimensional encoding in the amygdala.Behavioural brain research · 2021Review
- What is dopamine doing in model-based reinforcement learning?Current opinion in behavioral sciences · 2021Article
- Dopamine, Prediction Error and Beyond.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- State-specific gating of salient cues by midbrain dopaminergic input to basal amygdala.Nature neuroscience · 2019Article
- The basolateral amygdala regulation of complex cognitive behaviours in the five-choice serial reaction time task.Psychopharmacology · 2019Article
- Ventral Tegmental Dopamine Neurons Participate in Reward Identity Predictions.Current biology : CB · 2019Article
- Article
- Dynamic Interaction between Reinforcement Learning and Attention in Multidimensional Environments.Neuron · 2017Article
- The Dopamine Prediction Error: Contributions to Associative Models of Reward Learning.Frontiers in psychology · 2017Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundNeural activity in basolateral amygdala has recently been shown to reflect surprise or attention as predicted by the Pearce-Kaye-Hall model (PKH)--an influential model of associative learning. Theoretically, a PKH attentional signal originates in prediction errors of the kind associated with phasic firing of dopamine neurons. This requirement for prediction errors, coupled with projections from the midbrain dopamine system into basolateral amygdala, suggests that the PKH signal in amygdala may depend on dopaminergic input.
methodsTo test this, we recorded single unit activity in basolateral amygdala in rats with 6-hydroxydopamine or sham lesions of the ipsilateral midbrain region. Neurons were recorded as the rats performed a task previously used to demonstrate both dopaminergic reward prediction errors and attentional signals in basolateral amygdala neurons.
resultsWe found that neurons recorded in sham lesioned rats exhibited the same attention-related PKH signal observed in previous studies. By contrast, neurons recorded in rats with ipsilateral 6-hydroxydopamine lesions failed to show attentional signaling.
conclusionsThese results indicate a linkage between the neural instantiations of the basolateral complex of the amygdala attentional signal and dopaminergic prediction errors. Such a linkage would have important implications for understanding both normal and aberrant learning and behavior, particularly in diseases thought to have a primary effect on dopamine systems, such as addiction and schizophrenia.
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