Evidence map›Paper›PMID 22762958›Full record

Trial reportAddictive behaviors2012

A comparison of three smokeless tobacco dependence measures.

Jon O Ebbert, Herbert H Severson, Brian G Danaher, Darrell R Schroeder, Elbert D Glover

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Addictive behaviors, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Interventions for smokeless tobacco use cessation.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Trial
  3. Nicotine Metabolite Ratio Is Associated With Lozenge Use But Not Quitting in Smokeless Tobacco Users.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016
    Trial
  4. Randomized trial of nicotine lozenges and phone counseling for smokeless tobacco cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015
    Trial
  5. Randomized controlled trial of MyLastDip: a Web-based smokeless tobacco cessation program for chewers ages 14-25.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jon O EbbertMayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. ebbert.jon@mayo.edu
Herbert H Severson
Brian G Danaher
Darrell R Schroeder
Elbert D Glover

Funding

XChew Net--Internet Smokeless Tobacco CessationR01CA084225 · NCI · OREGON RESEARCH INSTITUTE · PI SEVERSON, HERBERT H · 2001 to 2011
$3.5M
Efficacy of Bupropion for Treating Spit Tobacco UsersR01CA090884 · NCI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI DALE, LOWELL C · 2002 to 2005
$2.5M
Evaluating Nicoting Lozenges for Treatment of Smokeless Tobacco AddictionR01CA121165 · NCI · MAYO CLINIC ROCHESTER · PI EBBERT, JON O. · 2006 to 2009
$2.0M
NCI NIH HHS CA 121165NCI NIH HHS CA 84225NCI NIH HHS CA 90884NCI NIH HHS R01 CA084225NCI NIH HHS R01 CA090884NCI NIH HHS R01 CA121165
6 · The paper itself

Abstract

Smokeless tobacco (ST) use is associated with tobacco dependence and long-term adverse health consequences. Clinical and research tools that can accurately assess ST dependence are needed to improve research and treatment of ST users. Measures of ST dependence have been developed to address this need. We used data from a study evaluating the effectiveness of bupropion sustained release for the treatment of ST use (N=225) to compare the Fagerström Tolerance Questionnaire for Smokeless Tobacco (FTQ-ST) users, the Severson Smokeless Tobacco Dependency Scale (SSTDS), and the Glover-Nilsson Smokeless Tobacco Behavioral Questionnaire (GN-STBQ). We observed that despite the intention of the scale: (1) all scales were significantly correlated with ST cans consumed per week; (2) the FTQ-ST was significantly correlated with serum nicotine and cotinine concentrations and craving; (3) the GN-STBQ and SSTDS were significantly associated with both craving and withdrawal; and (4) none of the scales were significantly associated with ST abstinence. When all of the scales were entered simultaneously in a multivariable analysis, the SSTDS was the only scale independently associated with withdrawal and craving. As when used with cigarette smokers, the FTQ-ST appeared to measure the construct of physical dependence. The GN-STBQ and SSTDS, designed to measure broader constructs of dependence, were found to predict both withdrawal and craving which may be advantageous in clinical settings. The GN-STBQ and the FTQ-ST did not contribute significantly to the prediction of withdrawal and craving beyond what was accomplished using the SSTDS. The use of the scales is discussed in terms of clinical usefulness and how each scale might assess differing aspects of tobacco dependence.

Indexed as

Tobacco, SmokelessAdultAgedBupropionDopamine Uptake InhibitorsDouble-Blind MethodHumansMaleMiddle AgedPsychiatric Status Rating ScalesPsychometricsSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use Cessation DevicesTobacco Use DisorderYoung AdultBupropionDopamine Uptake Inhibitors

Identifiers

PMID22762958
PMCPMC3401334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.