ArticleAtherosclerosis2012
Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage.
Article in Atherosclerosis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Quantitative Analysis of Intracranial Atherosclerosis and Its Correlation with Ischemic Cerebrovascular Disease and Prognosis.Brain sciences · 2025Article
- Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study.Scientific reports · 2023Observational
- Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia.International journal of molecular sciences · 2022Article
- Proximal Region of Carotid Atherosclerotic Plaque Shows More Intraplaque Hemorrhage: The Plaque at Risk Study.AJNR. American journal of neuroradiology · 2022Article
- Morphological and Physiological Characteristics of Ruptured Plaques in Native Arteries and Neoatherosclerotic Segments: An OCT-Based and Computational Fluid Dynamics Study.Frontiers in cardiovascular medicine · 2022Article
- Intracranial Arterial Calcification and Intracranial Atherosclerosis: Close but Different.Frontiers in neurology · 2022Article
- Histology-Verified Intracranial Artery Calcification and Its Clinical Relevance With Cerebrovascular Disease.Frontiers in neurology · 2021Review
- Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability.Therapeutics and clinical risk management · 2021Article
- CT imaging features of carotid artery plaque vulnerability.Annals of translational medicine · 2020Review
- Carotid intraplaque haemorrhage: pathogenesis, histological classification, imaging methods and clinical value.Annals of translational medicine · 2020Review
- Carotid plaque imaging profiling in subjects with risk factors (diabetes and hypertension).Cardiovascular diagnosis and therapy · 2020Review
- Article
- Stress-Relaxation and Cyclic Behavior of Human Carotid Plaque Tissue.Frontiers in bioengineering and biotechnology · 2020Article
- Studying the Factors of Human Carotid Atherosclerotic Plaque Rupture, by Calculating Stress/Strain in the Plaque, Based on CEUS Images: A Numerical Study.Frontiers in neuroinformatics · 2020Article
- The correlation between calcification in carotid plaque and stroke: calcification may be a risk factor for stroke.International journal of clinical and experimental pathology · 2019Article
- Superficial and multiple calcifications and ulceration associate with intraplaque hemorrhage in the carotid atherosclerotic plaque.European radiology · 2018Article
- Association of severity between carotid and intracranial artery atherosclerosis.Annals of clinical and translational neurology · 2018Article
- Molecular dynamics simulations indicate that deoxyhemoglobin, oxyhemoglobin, carboxyhemoglobin, and glycated hemoglobin under compression and shear exhibit an anisotropic mechanical behavior.Journal of biomolecular structure & dynamics · 2018Article
- Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.Scientific reports · 2016Article
- Contrast-Enhanced Quantitative Intravascular Elastography: The Impact of Microvasculature on Model-Based Elastography.Ultrasound in medicine & biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveIntraplaque hemorrhage is an increasingly recognized contributor to plaque instability. Neovascularization of plaque is believed to facilitate the entry of inflammatory and red blood cells (RBC). Under physiological conditions, neovessels are subject to mechanical loading from the deformation of atherosclerotic plaque by blood pressure and flow. Local mechanical environments around neovessels and their relevant pathophysiologic significance have not yet been examined. METHODS AND
resultsFour carotid plaque samples removed at endarcterectomy were collected for histopathological examination. Neovessels and other components were manually segmented to build numerical models for mechanical analysis. Each component was assumed to be non-linear isotropic, piecewise homogeneous and incompressible. The results indicated that local maximum principal stress and stretch and their variations during one cardiac cycle were greatest around neovessels. Neovessels surrounded by RBC underwent a much larger stretch during systole than those without RBCs present nearby (median [inter quartile range]; 1.089 [1.056, 1.131] vs. 1.034 [1.020, 1.067]; p<0.0001) and much larger stress (5.3kPa [3.4, 8.3] vs. 3.1kPa [1.6, 5.5]; p<0.0001) and stretch (0.0282 [0.0190, 0.0427] vs. 0.0087 [0.0045, 0.0185]; p<0.0001) variations during the cardiac cycle.
conclusionsLocal critical mechanical conditions may lead to the rupture of neovessels resulting in the formation and expansion of intraplaque hemorrhage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.