ReviewCanadian journal of psychiatry. Revue canadienne de psychiatrie2012
Molecular genetics of the psychosis phenotype.
Review in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Primary Psychosis: Risk and Protective Factors and Early Detection of the Onset.Diagnostics (Basel, Switzerland) · 2021Review
- Izmir Mental Health Cohort for Gene-Environment Interaction in Psychosis (TürkSch): Assessment of the Extended and Transdiagnostic Psychosis Phenotype and Analysis of Attrition in a 6-Year Follow-Up of a Community-Based Sample.Frontiers in psychiatry · 2019Article
- Perinatal Asphyxia in Rat Alters Expression of Novel Schizophrenia Risk Genes.Frontiers in molecular neuroscience · 2017Article
- No association between NRG1 and ErbB4 genes and psychopathological symptoms of schizophrenia.Neuromolecular medicine · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveRelative to recent successes in elucidating the genetic mechanisms associated with complex diseases, including macular degeneration, diabetes mellitus, type 2, heart disease, and cancer, molecular genetic approaches to psychiatric illness have met with more limited success. While factors such as small allelic effects, allelic heterogeneity, and variation in population substructure have received considerable attention in attempt to explain the paucity of significant results in psychiatric genetics, significantly less focus has been directed toward phenotypic factors.
methodData derived from molecular genetic studies of the psychosis phenotype in patients with a range of psychiatric illnesses are reviewed.
resultsAvailable data suggest that genes do not respect the boundaries of the current diagnostic system but may confer risk for symptom-based phenotypic variation that traverses those boundaries.
conclusionsMolecular genetic studies offer convincing evidence for a relation between genetic variation and symptom-based phenotypic variation within psychiatric illness. These data may provide novel insights into the pathophysiology of schizophrenia and other related disorders. The exploration of relations between genetic variation and symptom variation that traverses traditional diagnostic boundaries may ultimately lead to more refined classification systems that more closely reflect the genetic etiology of psychiatric illness.
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