Evidence map›Paper›PMID 22762250›Full record

ArticleACS nano2012

Mechanism of magnetic relaxation switching sensing.

Changwook Min, Huilin Shao, Monty Liong, Tae-Jong Yoon, Ralph Weissleder, Hakho Lee

Abstract read
In one paragraph

Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
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  11. Article
  12. Review
  13. Design and synthesis of magnetic nanoparticles for biomedical diagnostics.Quantitative imaging in medicine and surgery · 2018
    Review
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Changwook MinCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA.
Huilin Shao
Monty Liong
Tae-Jong Yoon
Ralph Weissleder
Hakho Lee

Funding

TREATMENT OF CANCER WITH siRNA DELVIERED BY NANOPARTICLESU54CA119349 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2005 to 2009
$20.5M
Translational Program of Excellence in NanotechnologyU01HL080731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2005 to 2009
$14.9M
Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
Magnetic nanoswitches for sensing biomoleculesR01EB004626 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2004 to 2012
$3.2M
MAGNETIC NANOSENSORS FOR BIOMEDICAL ANALYSES OF MICROVESICLESR01HL113156 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO · 2012 to 2016
$2.1M
NCI NIH HHS T32 CA079443NCI NIH HHS T32-CA79443NCI NIH HHS U54 CA119349NCI NIH HHS U54-CA119349NHLBI NIH HHS R01 HL113156NHLBI NIH HHS U01 HL080731NHLBI NIH HHS U01-HL080731NIBIB NIH HHS 2R01EB004626NIBIB NIH HHS R01 EB004626
6 · The paper itself

Abstract

Magnetic relaxation switching (MRSw) assays that employ target-induced aggregation (or disaggregation) of magnetic nanoparticles (MNPs) can be used to detect a wide range of biomolecules. The precise working mechanisms, however, remain poorly understood, often leading to confounding interpretation. We herein present a systematic and comprehensive characterization of MRSw sensing. By using different types of MNPs with varying physical properties, we analyzed the nature and transverse relaxation modes for MRSw detection. The study found that clustered MNPs are universally in a diffusion-limited fractal state (dimension of ~2.4). Importantly, a new model for transverse relaxation was constructed that accurately recapitulates observed MRSw phenomena and predicts the MRSw detection sensitivities and dynamic ranges.

Indexed as

Models, ChemicalComputer SimulationMagnetic FieldsMagnetite NanoparticlesMaterials TestingMagnetite Nanoparticles

Identifiers

PMID22762250
PMCPMC3429660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.