Evidence map›Paper›PMID 22762017›Full record

ReviewCold Spring Harbor perspectives in medicine2012

Human endothelial progenitor cells.

Mervin C Yoder

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

193 citing papers in PubMed, 1 synthesis or guideline pooled it, 401 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. CD34Histology and histopathology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Isolation of endothelial progenitor cells from human adipose tissue.International journal of obesity (2005) · 2025
    Article
  11. Direct in vivo reprogramming to relieve tissue ischemia via induced vasculogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  12. Endothelial Progenitor Cells: Disease Markers and Potential Therapy in Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025
    Review
  13. Endothelial dysfunction in chronic kidney disease: a clinical perspective.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Endothelial Dysfunction with Aging: Does Sex Matter?International journal of molecular sciences · 2024
    Article
  20. Review

133 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mervin C YoderDepartment of Pediatrics, Herman B Wells Center for Pediatrics Research, Indiana University School of Medicine, Indianapolis, Indiana, USA. myoder@iupui.edu
Indiana University School of Medicine

Funding

Lymphopoietic development in the extra-embryonic yolk sacR01AI080759 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI YODER, MERVIN C. · 2009 to 2013
$1.8M
Collagen Cross-links Direct Matrix-Induced Vasculogenesis Via Tunable PathwaysR01HL109602 · NHLBI · PURDUE UNIVERSITY · PI VOYTIK-HARBIN, SHERRY L, YODER, MERVIN C. · 2011 to 2014
$1.5M
NHLBI NIH HHS R01 HL109602NIAID NIH HHS R01 AI080759
6 · The paper itself

Abstract

Human endothelial progenitor cells (EPCs) have been generally defined as circulating cells that express a variety of cell surface markers similar to those expressed by vascular endothelial cells, adhere to endothelium at sites of hypoxia/ischemia, and participate in new vessel formation. Although no specific marker for an EPC has been identified, a panel of markers has been consistently used as a surrogate marker for cells displaying the vascular regenerative properties of the putative EPC. However, it is now clear that a host of hematopoietic and vascular endothelial subsets display the same panel of antigens and can only be discriminated by an extensive gene expression analysis or use of a variety of functional assays that are not often applied. This article reviews our current understanding of the many cell subsets that constitute the term EPC and provides a concluding perspective as to the various roles played by these circulating or resident cells in vessel repair and regeneration in human subjects.

Indexed as

RegenerationAntigens, SurfaceBlood VesselsEndothelial CellsHumansStem CellsAntigens, Surface

Identifiers

PMID22762017
PMCPMC3385946
OpenAlexW2144366742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.