ArticlePloS one2012
Current and calcium responses to local activation of axonal NMDA receptors in developing cerebellar molecular layer interneurons.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells.The Journal of physiology · 2026Article
- Activation of GluN2D-containing NMDA receptors promotes development of axons and axon-carrying dendrites of cortical interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Spatial and temporal aspects of neuronal calcium and sodium signals measured with low-affinity fluorescent indicators.Pflugers Archiv : European journal of physiology · 2024Review
- Recurrent Circuits Amplify Corticofugal Signals and Drive Feedforward Inhibition in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Article
- Presynaptic release-regulating NMDA receptors in isolated nerve terminals: A narrative review.British journal of pharmacology · 2021Review
- Influence of spatially segregated IPProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Differentially poised vesicles underlie fast and slow components of release at single synapses.The Journal of general physiology · 2020Article
- Incomplete vesicular docking limits synaptic strength under high release probability conditions.eLife · 2020Article
- Circuit-specific control of the medial entorhinal inputs to the dentate gyrus by atypical presynaptic NMDARs activated by astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Role of NMDA Receptors in Alzheimer's Disease.Frontiers in neuroscience · 2019Review
- Temporal integration and 1/Journal of neurophysiology · 2017Article
- NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups.Open biology · 2017Article
- Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction.Nature neuroscience · 2016Article
- Presynaptic GluN2D receptors detect glutamate spillover and regulate cerebellar GABA release.Journal of neurophysiology · 2016Article
- Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity.Trends in neurosciences · 2016Review
- Tactile Stimulation Evokes Long-Lasting Potentiation of Purkinje Cell Discharge In Vivo.Frontiers in cellular neuroscience · 2016Article
- Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurons.Frontiers in synaptic neuroscience · 2015Article
- NMDA receptor antagonists ketamine and Ro25-6981 inhibit evoked release of glutamate in vivo in the subiculum.Translational psychiatry · 2014Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In developing cerebellar molecular layer interneurons (MLIs), NMDA increases spontaneous GABA release. This effect had been attributed to either direct activation of presynaptic NMDA receptors (preNMDARs) or an indirect pathway involving activation of somato-dendritic NMDARs followed by passive spread of somatic depolarization along the axon and activation of axonal voltage dependent Ca(2+) channels (VDCCs). Using Ca(2+) imaging and electrophysiology, we searched for preNMDARs by uncaging NMDAR agonists either broadly throughout the whole field or locally at specific axonal locations. Releasing either NMDA or glutamate in the presence of NBQX using short laser pulses elicited current transients that were highly sensitive to the location of the spot and restricted to a small number of varicosities. The signal was abolished in the presence of high Mg(2+) or by the addition of APV. Similar paradigms yielded restricted Ca(2+) transients in interneurons loaded with a Ca(2+) indicator. We found that the synaptic effects of NMDA were not inhibited by blocking VDCCs but were impaired in the presence of the ryanodine receptor antagonist dantrolene. Furthermore, in voltage clamped cells, bath applied NMDA triggers Ca(2+) elevations and induces neurotransmitter release in the axonal compartment. Our results suggest the existence of preNMDARs in developing MLIs and propose their involvement in the NMDA-evoked increase in GABA release by triggering a Ca(2+)-induced Ca(2+) release process mediated by presynaptic Ca(2+) stores. Such a mechanism is likely to exert a crucial role in various forms of Ca(2+)-mediated synaptic plasticity.
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