ArticlePloS one2012
Viability conditions for a compartmentalized protometabolic system: a semi-empirical approach.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- When Is a Reaction Network a Metabolism? Criteria for Simple Metabolisms That Support Growth and Division of Protocells.Life (Basel, Switzerland) · 2021Article
- Ion shuttling between emulsion droplets by crown ether modified gold nanoparticles.Nanoscale advances · 2021Article
- The optimal size of protocells from simple entropic considerations.European biophysics journal : EBJ · 2019Article
- Permeability-driven selection in a semi-empirical protocell model: the roots of prebiotic systems evolution.Scientific reports · 2017Article
- Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research.Beilstein journal of organic chemistry · 2017Article
- Emergent chemical behavior in variable-volume protocells.Life (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and simulation results to establish the conditions under which a reaction network with a catalytically closed organization (more specifically, an (M,R-system) would overcome the potential problem of self-suffocation that arises from the limited accessibility of nutrients to its internal reaction domain. The relationship between the permeability of the membrane, the lifetime of the key catalysts and their efficiency (reaction rate enhancement) turns out to be critical. In particular, we show how permeability values constrain the characteristic time scale of the bounded protometabolic processes. From this concrete and illustrative example we finally extend the discussion to a wider evolutionary context.
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Registered trials
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