ArticlePloS one2012
Glucocorticoid and estrogen receptors are reduced in mitochondria of lung epithelial cells in asthma.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Hormone-dependent immune regulation shapes asthma heterogeneity across the female lifespan.Frontiers in immunology · 2026Review
- Targeting mitochondrial function as a potential therapeutic approach for allergic asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Role of Paraoxonase 2 in Airway Epithelial Response to Oxidant Stress.Antioxidants (Basel, Switzerland) · 2024Article
- Mitochondrial signal transduction.Cell metabolism · 2022Review
- Effects of Oral Exposure to Low-Dose Bisphenol S on Allergic Asthma in Mice.International journal of molecular sciences · 2022Article
- Nanoparticle-Induced Airway Eosinophilia Is Independent of ILC2 Signaling but Associated With Sex Differences in Macrophage Phenotype Development.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen.International journal of molecular sciences · 2021Article
- Mitochondrial Glucocorticoid Receptors and Their Actions.International journal of molecular sciences · 2021Review
- The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD.Oxidative medicine and cellular longevity · 2021Review
- Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression.Frontiers in neuroscience · 2018Review
- Estrogens regulate life and death in mitochondria.Journal of bioenergetics and biomembranes · 2017Review
- Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.Oxidative medicine and cellular longevity · 2017Article
- Active Ingredients of Epimedii Folium and Ligustri Lucidi Fructus Balanced GR/HSP90 to Improve the Sensitivity of Asthmatic Rats to Budesonide.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors.Nature reviews. Molecular cell biology · 2016Review
- Integrating mitochondriomics in children's environmental health.Journal of applied toxicology : JAT · 2015Review
- Estrogen Signaling Modulates Allergic Inflammation and Contributes to Sex Differences in Asthma.Frontiers in immunology · 2015Review
- Sexually-dimorphic targeting of functionally-related genes in COPD.BMC systems biology · 2014Article
- Estrongenic steroid hormones in lung cancer.Seminars in oncology · 2014Review
- Smoking out reproductive hormone actions in lung cancer.Molecular cancer research : MCR · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial glucocorticoid (mtGR) and estrogen (mtER) receptors participate in the coordination of the cell's energy requirement and in the mitochondrial oxidative phosphorylation enzyme (OXPHOS) biosynthesis, affecting reactive oxygen species (ROS) generation and induction of apoptosis. Although activation of mtGR and mtER is known to trigger anti-inflammatory signals, little information exists on the presence of these receptors in lung tissue and their role in respiratory physiology and disease. Using a mouse model of allergic airway inflammation disease and applying confocal microscopy, subcellular fractionation, and Western blot analysis we showed mitochondrial localization of GRα and ERβ in lung tissue. Allergic airway inflammation caused reduction in mtGRα, mtERβ, and OXPHOS enzyme biosynthesis in lung cells mitochondria and particularly in bronchial epithelial cells mitochondria, which was accompanied by decrease in lung mitochondrial mass and induction of apoptosis. Confirmation and validation of the reduction of the mitochondrial receptors in lung epithelial cells in human asthma was achieved by analyzing autopsies from fatal asthma cases. The presence of the mitochondrial GRα and ERβ in lung tissue cells and especially their reduction in bronchial epithelial cells during allergic airway inflammation suggests a crucial role of these receptors in the regulation of mitochondrial function in asthma, implicating their involvement in the pathophysiology of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.