ArticlePloS one2012
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of genome-wide research on psychotic experiences and negative symptom traits: new revelations and implications for psychiatry.Human molecular genetics · 2018Pooled it
- Associations between psychotic experience dimensions and polygenic liability to schizophrenia in a longitudinal birth cohort.BJPsych open · 2025Article
- Association of Polygenic Risk Scores for Schizophrenia with Psychosis-Proneness Indicators in the General Population: A Narrative Review.Consortium psychiatricum · 2025Review
- Polygenic risk scores analyses of psychiatric and metabolic traits with antipsychotic-induced weight gain in schizophrenia: an exploratory study.The pharmacogenomics journal · 2023Article
- Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls: Genetic Risk and Outcome of Psychosis (GROUP) study.Scientific reports · 2023Article
- Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.Psychological medicine · 2023Article
- Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study.Epidemiology and psychiatric sciences · 2022Article
- Do we measure or compute polygenic risk scores? Why language matters.Human genetics · 2022Article
- Polygenic risk scores across the extended psychosis spectrum.Translational psychiatry · 2021Article
- A genetic risk score using human chromosomal-scale length variation can predict schizophrenia.Scientific reports · 2021Article
- The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.Translational psychiatry · 2021Article
- Genetic overlap between psychotic experiences in the community across age and with psychiatric disorders.Translational psychiatry · 2020Article
- Pathways Between a Polygenic Score for Educational Attainment and Higher Educational Attainment in an African American Sample.Behavior genetics · 2020Article
- Schizophrenia polygenic risk score and 20-year course of illness in psychotic disorders.Translational psychiatry · 2019Article
- Multi-Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying.JAMA psychiatry · 2019Article
- Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders.The British journal of psychiatry : the journal of mental science · 2018Article
- Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort.Translational psychiatry · 2018Article
- Multivariate Pattern Analysis of Genotype-Phenotype Relationships in Schizophrenia.Schizophrenia bulletin · 2018Article
- Investigating the genetic architecture of general and specific psychopathology in adolescence.Translational psychiatry · 2018Article
- A tutorial on conducting genome-wide association studies: Quality control and statistical analysis.International journal of methods in psychiatric research · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we identified five quantitative measures of schizophrenia (positive, negative, disorganisation, mania, and depression scores). The aim of this study is to examine the association between a direct measure of genetic risk of schizophrenia and the five quantitative measures of psychosis. Estimates of the log of the odds ratios of case/control allelic association tests were obtained from the Psychiatric GWAS Consortium (PGC) (minus our sample) which included genome-wide genotype data of 8,690 schizophrenia cases and 11,831 controls. These data were used to calculate genetic risk scores in 314 schizophrenia cases and 148 controls from the Netherlands for whom genotype data and quantitative symptom scores were available. The genetic risk score of schizophrenia was significantly associated with case-control status (p<0.0001). In the case-control sample, the five psychosis dimensions were found to be significantly associated with genetic risk scores; the correlations ranged between.15 and.27 (all p<.001). However, these correlations were not significant in schizophrenia cases or controls separately. While this study confirms the presence of a genetic risk for schizophrenia as categorical diagnostic trait, we did not find evidence for the genetic risk underlying quantitative schizophrenia symptom dimensions. This does not necessarily imply that a genetic basis is nonexistent, but does suggest that it is distinct from the polygenic risk score for schizophrenia.
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