ArticlePloS one2012
Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 80 citations in OpenAlex.
- Self-referential processing as the biological switch between classical and quantum functioning of the brain.Frontiers in human neuroscience · 2026Article
- Quantum theories of consciousness: a critical review of feasibility, philosophical sufficiency, and empirical testability.Frontiers in psychology · 2026Review
- A Unified Model of Consciousness: Glycoprotein Patterns in Memory Processes and Quantum Entanglement.Current medicinal chemistry · 2026Article
- Microtubule-modulating drugs alter sensitivity to isoflurane in mice.BMC anesthesiology · 2025Article
- The quantum-classical complexity of consciousness and orchestrated objective reduction.Frontiers in human neuroscience · 2025Article
- An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Electronic Energy Migration in Microtubules.ACS central science · 2023Article
- Review
- Molecular details of aluminium-amyloid β peptide interaction by nuclear magnetic resonance.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Magnetic field effects in biology from the perspective of the radical pair mechanism.Journal of the Royal Society, Interface · 2022Review
- Radical pairs may play a role in microtubule reorganization.Scientific reports · 2022Article
- Consciousness, Cognition and the Neuronal Cytoskeleton - A New Paradigm Needed in Neuroscience.Frontiers in molecular neuroscience · 2022Article
- Identification of individuals at risk for postoperative cognitive dysfunction (POCD).Therapeutic advances in neurological disorders · 2022Review
- The association between antidepressants use and development of cognitive impairment among older women diagnosed with breast cancer.European geriatric medicine · 2020Article
- The finer scale of consciousness: quantum theory.Annals of translational medicine · 2019Review
- Recent progress on the molecular pharmacology of propofol.F1000Research · 2018Review
- Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease.Journal of photochemistry and photobiology. B, Biology · 2017Article
- Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction.Scientific reports · 2017Article
- Common general anesthetic propofol impairs kinesin processivity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Linoleic acid: Is this the key that unlocks the quantum brain? Insights linking broken symmetries in molecular biology, mood disorders and personalistic emergentism.BMC neuroscience · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuronal cytoskeleton is extremely complex, it is no wonder that a startling number of neurodegenerative disorders (including but not limited to Alzheimer's disease, Parkinson's disease and Huntington's disease) share the common feature of a dysfunctional neuronal cytoskeleton. Recently, concern has been raised about a possible link between anesthesia, post-operative cognitive dysfunction, and the exacerbation of neurodegenerative disorders. Experimental investigations suggest that anesthetics bind to and affect cytoskeletal microtubules, and that anesthesia-related cognitive dysfunction involves microtubule instability, hyper-phosphorylation of the microtubule-associated protein tau, and tau separation from microtubules. However, exact mechanisms are yet to be identified. In this paper the interaction of anesthetics with the microtubule subunit protein tubulin is investigated using computer-modeling methods. Homology modeling, molecular dynamics simulations and surface geometry techniques were used to determine putative binding sites for volatile anesthetics on tubulin. This was followed by free energy based docking calculations for halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) on the tubulin body, and C-terminal regions for specific tubulin isotypes. Locations of the putative binding sites, halothane binding energies and the relation to cytoskeleton function are reported in this paper.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.